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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Walter Johnson* | 3533 | 1907-1927 | |
| 2 | Satchel Paige | 3344 | 1927-1951 | |
| 3 | Joe Williams* | 3256 | 1907-1930 | |
| 4 | Cy Young* | 2920 | 1890-1911 | |
| 5 | Eddie Plank* | 2672 | 1901-1917 | |
| 6 | Charles Bender* | 2614 | 1903-1924 | |
| 7 | Bill Foster* | 2540 | 1923-1949 | |
| 8 | Rube Waddell* | 2534 | 1897-1910 | |
| 9 | Lefty Grove* | 2459 | 1925-1945 | |
| 10 | Christy Mathewson* | 2408 | 1900-1916 | |
| 11 | Red Ames* | 2300 | 1903-1919 | |
| 12 | Luis Tiant Sr. | 2242 | 1926-1951 | |
| 13 | Bob Feller# | 2219 | 1936-1954 | |
| 14 | Van Mungo# | 2215 | 1931-1954 | |
| 15 | Kid Nichols* | 2164 | 1890-1906 | |
| 16 | Jose Mendez* | 2120 | 1907-1926 | |
| 17 | Grover Cleveland Alexander* | 2103 | 1911-1930 | |
| 18 | Carl Hubbell* | 2095 | 1928-1948 | |
| 19 | Dazzy Vance | 2089 | 1921-1935 | |
| 20 | Martin Dihigo | 2031 | 1924-1946 | |
| 21 | Rube Marquard | 2024 | 1908-1925 | |
| 22 | Paul Derringer | 2001 | 1931-1952 | |
| 23 | Ray Brown | 1976 | 1931-1953 | |
| 24 | Larry French | 1953 | 1929-1953 | |
| 25 | Amos Rusie | 1937 | 1889-1901 | |
| 26 | Eddie Cicotte* | 1927 | 1906-1923 | |
| 27 | Red Ruffing | 1900 | 1924-1946 | |
| 28 | Bill Donovan | 1882 | 1898-1918 | |
| 29 | Hilton Smith | 1855 | 1932-1952 | |
| 30 | Ed Walsh* | 1846 | 1904-1914 | |
| 31 | Roy Partlow# | 1803 | 1934-1954 | |
| 32 | Leon Day# | 1793 | 1935-1954 | |
| 33 | Andy Cooper | 1785 | 1920-1942 | |
| 34 | Ed Brandt | 1758 | 1928-1950 | |
| 35 | Dutch Leonard | 1723 | 1913-1925 | |
| 36 | Henry McHenry# | 1714 | 1931-1954 | |
| 37 | Bob Shawkey | 1698 | 1913-1927 | |
| 38 | Lee Grissom | 1675 | 1934-1953 | |
| 39 | Tex Carleton | 1670 | 1932-1951 | |
| 40 | Gus Weyhing | 1663 | 1887-1901 | |
| 41 | Jack Powell | 1660 | 1897-1912 | |
| 42 | Eppa Rixey | 1642 | 1912-1933 | |
| 43 | Hippo Vaughn | 1638 | 1909-1921 | |
| 44 | Vic Willis | 1625 | 1898-1910 | |
| 45 | Barney Brown | 1592 | 1931-1952 | |
| 46 | Tommy Bridges | 1574 | 1930-1944 | |
| 47 | Doc White | 1571 | 1901-1912 | |
| 48 | Leroy Matlock | 1548 | 1929-1952 | |
| 49 | Johnny Vander Meer | 1541 | 1937-1950 | |
| 50 | Dick Redding | 1539 | 1911-1931 | |
| 51 | Mordecai Brown* | 1479 | 1903-1916 | |
| 52 | Bill Holland | 1460 | 1919-1941 | |
| 53 | Jack Quinn | 1453 | 1909-1932 | |
| 54 | Ted Trent | 1445 | 1927-1949 | |
| 55 | Burleigh Grimes | 1432 | 1916-1934 | |
| 56 | Babe Adams* | 1427 | 1906-1926 | |
| 57 | Cy Falkenberg | 1421 | 1904-1917 | |
| 58 | Joe Wood | 1409 | 1908-1922 | |
| 59 | Schoolboy Rowe# | 1402 | 1933-1954 | |
| 60 | Virgil Trucks# | 1390 | 1941-1954 | |
| 61 | Pat Malone | 1381 | 1928-1947 | |
| 62 | Willie Mitchell | 1378 | 1909-1919 | |
| 62 | Earl Moore | 1378 | 1901-1913 | |
| 64 | Bill Doak | 1374 | 1913-1929 | |
| 65 | Spud Chandler | 1370 | 1937-1952 | |
| 66 | Lefty Gomez | 1353 | 1930-1942 | |
| 67 | Rube Benton | 1339 | 1911-1925 | |
| 68 | Terris McDuffie | 1337 | 1930-1950 | |
| 69 | Hal Newhouser# | 1335 | 1940-1954 | |
| 70 | Bobo Newsom | 1320 | 1929-1948 | |
| 71 | Roy Welmaker | 1304 | 1933-1952 | |
| 72 | Red Faber | 1299 | 1914-1932 | |
| 73 | Nap Rucker | 1292 | 1907-1916 | |
| 74 | Claude Hendrix | 1282 | 1911-1920 | |
| 75 | Porter Moss# | 1265 | 1932-1954 | |
| 76 | Claude Passeau | 1252 | 1935-1954 | |
| 77 | Barney Morris | 1234 | 1932-1947 | |
| 78 | Tom Hughes | 1231 | 1900-1913 | |
| 79 | Roosevelt Davis | 1216 | 1924-1950 | |
| 80 | Lefty Tyler | 1209 | 1910-1921 | |
| 81 | Herb Pennock | 1206 | 1912-1934 | |
| 82 | Fritz Ostermueller | 1199 | 1934-1952 | |
| 83 | Bob Ewing | 1197 | 1902-1910 | |
| 84 | Dolf Luque | 1196 | 1914-1935 | |
| 85 | Jack Chesbro | 1195 | 1899-1909 | |
| 86 | Frank Smith | 1188 | 1904-1911 | |
| 87 | Johnny Allen | 1187 | 1932-1942 | |
| 88 | Vean Gregg | 1186 | 1911-1925 | |
| 88 | Lon Warneke | 1186 | 1930-1949 | |
| 90 | Webster McDonald | 1180 | 1922-1940 | |
| 91 | Guy Morton | 1178 | 1914-1924 | |
| 92 | Harry Howell | 1170 | 1898-1909 | |
| 93 | Larry Cheney | 1164 | 1911-1919 | |
| 94 | Bill Dinneen | 1161 | 1898-1909 | |
| 95 | John Donaldson | 1159 | 1913-1921 | |
| 96 | Dizzy Dean | 1154 | 1930-1940 | |
| 97 | Warren Spahn# | 1149 | 1945-1954 | |
| 98 | Hooks Wiltse | 1147 | 1904-1914 | |
| 99 | Bill Byrd | 1146 | 1932-1951 | |
| 99 | Waite Hoyt | 1146 | 1919-1944 |
