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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Amos Rusie | 341 | 1890 | |
| 2 | Amos Rusie | 337 | 1891 | |
| 3 | Rube Waddell | 299 | 1904 | |
| 4 | Amos Rusie | 288 | 1892 | |
| 5 | Rube Waddell | 279 | 1903 | |
| 6 | Rube Waddell | 276 | 1901 | |
| 7 | Christy Mathewson# | 266 | 1901 | |
| 8 | Rube Waddell | 261 | 1905 | |
| 9 | Noodles Hahn | 255 | 1901 | |
| 10 | Eddie Plank# | 251 | 1914 | |
| 11 | Joe Wood# | 248 | 1912 | |
| 11 | Rube Waddell | 248 | 1906 | |
| 13 | Walter Johnson# | 245 | 1912 | |
| 13 | Walter Johnson# | 245 | 1911 | |
| 13 | Tom Hughes | 245 | 1901 | |
| 16 | Red Ames# | 243 | 1904 | |
| 16 | Bill Donovan# | 243 | 1901 | |
| 18 | Doc White | 242 | 1901 | |
| 19 | Kid Nichols* | 240 | 1891 | |
| 19 | Joe Wood# | 240 | 1911 | |
| 21 | Cy Seymour | 239 | 1898 | |
| 22 | Joe Wood# | 238 | 1913 | |
| 22 | Hooks Wiltse | 238 | 1904 | |
| 24 | Rube Marquard# | 237 | 1911 | |
| 25 | Ed Walsh# | 229 | 1911 | |
| 25 | Red Ames# | 229 | 1905 | |
| 27 | Charles Bender# | 227 | 1905 | |
| 27 | Ed Walsh# | 227 | 1912 | |
| 29 | Jose Mendez# | 225 | 1910 | |
| 30 | Kid Nichols* | 222 | 1890 | |
| 30 | Kid Gleason | 222 | 1890 | |
| 32 | Rube Waddell | 221 | 1907 | |
| 32 | Rube Waddell | 221 | 1908 | |
| 32 | Walter Johnson# | 221 | 1914 | |
| 32 | Rube Marquard# | 221 | 1910 | |
| 36 | Ed Walsh# | 220 | 1910 | |
| 37 | Gus Weyhing | 219 | 1891 | |
| 38 | Rube Waddell | 218 | 1902 | |
| 38 | Walter Johnson# | 218 | 1910 | |
| 40 | Vean Gregg# | 217 | 1911 | |
| 41 | Jose Mendez# | 214 | 1908 | |
| 42 | Gus Weyhing | 213 | 1889 | |
| 43 | Walter Johnson# | 212 | 1913 | |
| 43 | Christy Mathewson# | 212 | 1904 | |
| 45 | Christy Mathewson# | 210 | 1908 | |
| 46 | Amos Rusie | 208 | 1893 | |
| 46 | Cy Falkenberg# | 208 | 1912 | |
| 48 | Vean Gregg# | 207 | 1912 | |
| 48 | Claude Hendrix# | 207 | 1912 | |
| 50 | Russ Ford | 206 | 1910 | |
| 50 | Christy Mathewson# | 206 | 1905 | |
| 52 | Eddie Plank# | 205 | 1905 | |
| 53 | Orval Overall | 204 | 1910 | |
| 53 | Hippo Vaughn# | 204 | 1914 | |
| 53 | Gus Weyhing | 204 | 1888 | |
| 53 | Frank Lange | 204 | 1911 | |
| 57 | Harry Krause | 203 | 1910 | |
| 57 | Fred Beebe# | 203 | 1906 | |
| 59 | Vic Willis | 202 | 1901 | |
| 59 | Dutch Leonard# | 202 | 1914 | |
| 59 | Rube Marquard# | 202 | 1912 | |
| 59 | Gus Weyhing | 202 | 1892 | |
| 63 | Amos Rusie | 201 | 1895 | |
| 63 | Charles Bender# | 201 | 1908 | |
| 65 | Joe Wood# | 200 | 1910 | |
| 65 | Willie Mitchell# | 200 | 1914 | |
| 67 | Harry Howell | 199 | 1905 | |
| 67 | Christy Mathewson# | 199 | 1909 | |
| 67 | Jose Mendez# | 199 | 1907 | |
| 70 | Cy Young | 198 | 1905 | |
| 70 | Frank Smith | 198 | 1908 | |
| 72 | Charles Bender# | 197 | 1910 | |
| 72 | Jack Pfiester | 197 | 1906 | |
| 72 | Red Ames# | 197 | 1908 | |
| 75 | Christy Mathewson# | 195 | 1903 | |
| 75 | Amos Rusie | 195 | 1894 | |
| 77 | Walter Johnson# | 194 | 1908 | |
| 77 | Hippo Vaughn# | 194 | 1913 | |
| 79 | Gus Weyhing | 193 | 1887 | |
| 80 | Charles Bender# | 192 | 1909 | |
| 81 | Jeff Tesreau# | 191 | 1914 | |
| 81 | Joe Wood# | 191 | 1914 | |
| 81 | Heinie Berger | 191 | 1908 | |
| 81 | Red Ames# | 191 | 1910 | |
| 85 | Red Ames# | 190 | 1906 | |
| 85 | Harry Krause | 190 | 1909 | |
| 85 | Ed Walsh# | 190 | 1905 | |
| 88 | Guy Morton# | 189 | 1914 | |
| 89 | Frank Lange | 188 | 1910 | |
| 89 | Charles Bender# | 188 | 1913 | |
| 89 | Orval Overall | 188 | 1908 | |
| 92 | Kid Nichols* | 187 | 1892 | |
| 92 | Charles Bender# | 187 | 1904 | |
| 92 | Jack Coombs# | 187 | 1910 | |
| 92 | Nap Rucker# | 187 | 1908 | |
| 92 | Walter Johnson# | 187 | 1907 | |
| 92 | Charles Bender# | 187 | 1911 | |
| 92 | Orval Overall | 187 | 1907 | |
| 99 | Frank Smith | 186 | 1904 | |
| 99 | Vean Gregg# | 186 | 1913 |
