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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Rube Waddell | 7.31 | 1908 | |
| 2 | Charles Bender# | 7.00 | 1908 | |
| 3 | Kid Nichols* | 6.50 | 1892 | |
| 4 | Red Ames# | 6.46 | 1911 | |
| 5 | Babe Adams# | 6.38 | 1913 | |
| 6 | Charles Bender# | 6.27 | 1903 | |
| 7 | Rube Waddell | 6.26 | 1901 | |
| 8 | Tom Hughes | 6.00 | 1909 | |
| 9 | Bill Donovan# | 5.94 | 1907 | |
| 10 | Eddie Plank# | 5.50 | 1903 | |
| 11 | Charles Bender# | 5.48 | 1912 | |
| 12 | Charles Bender# | 5.19 | 1913 | |
| 13 | Orval Overall | 5.06 | 1909 | |
| 13 | Charles Bender# | 5.06 | 1909 | |
| 15 | Rube Waddell | 5.00 | 1903 | |
| 16 | Rube Waddell | 4.86 | 1902 | |
| 17 | Jeff Tesreau# | 4.76 | 1914 | |
| 18 | Claude Hendrix# | 4.68 | 1912 | |
| 19 | Vean Gregg# | 4.50 | 1911 | |
| 19 | Joe Williams# | 4.50 | 1910 | |
| 21 | Frank Smith | 4.34 | 1908 | |
| 22 | Rube Marquard# | 4.24 | 1911 | |
| 23 | Mordecai Brown# | 4.01 | 1907 | |
| 24 | Mordecai Brown# | 4.00 | 1909 | |
| 24 | Christy Mathewson# | 4.00 | 1904 | |
| 26 | Harry Krause | 3.94 | 1909 | |
| 27 | George McConnell# | 3.86 | 1913 | |
| 28 | Joe Wood# | 3.79 | 1915 | |
| 29 | Vean Gregg# | 3.78 | 1913 | |
| 30 | Doc White | 3.71 | 1906 | |
| 30 | Christy Mathewson# | 3.71 | 1906 | |
| 32 | Jack Pfiester | 3.50 | 1907 | |
| 32 | Hooks Wiltse | 3.50 | 1906 | |
| 32 | Jesse Tannehill | 3.50 | 1903 | |
| 32 | Christy Mathewson# | 3.50 | 1911 | |
| 32 | Dutch Leonard# | 3.50 | 1915 | |
| 37 | Otto Hess | 3.38 | 1906 | |
| 38 | Addie Joss | 3.32 | 1905 | |
| 39 | Weldon Henley | 3.31 | 1903 | |
| 40 | George McQuillan# | 3.26 | 1908 | |
| 41 | Jeff Tesreau# | 3.24 | 1915 | |
| 42 | Joe Lake | 3.18 | 1910 | |
| 42 | Orval Overall | 3.18 | 1910 | |
| 44 | Red Ames# | 3.00 | 1905 | |
| 44 | Rube Marquard# | 3.00 | 1914 | |
| 44 | Babe Adams# | 3.00 | 1914 | |
| 44 | George Mullin | 3.00 | 1907 | |
| 44 | Cy Young | 3.00 | 1892 | |
| 49 | Mordecai Brown# | 2.81 | 1910 | |
| 50 | Cy Young | 2.67 | 1901 | |
| 51 | Dutch Leonard# | 2.65 | 1914 | |
| 51 | Charlie Smith | 2.65 | 1907 | |
| 53 | Jesse Tannehill | 2.57 | 1901 | |
| 54 | Eddie Plank# | 2.50 | 1908 | |
| 55 | George Winter | 2.45 | 1901 | |
| 56 | Jack Chesbro | 2.42 | 1907 | |
| 57 | Addie Joss | 2.12 | 1906 | |
| 57 | Russ Ford | 2.12 | 1910 | |
| 59 | Charles Bender# | 1.50 | 1911 | |
| 60 | Bill Bernhard | 1.12 | 1906 |
