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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Van Mungo# | 6.84 | 1931-1954 | |
| 2 | Charley Root | 6.10 | 1923-1940 | |
| 3 | Rube Waddell* | 5.82 | 1897-1910 | |
| 4 | Red Ames* | 5.73 | 1903-1919 | |
| 5 | Vean Gregg | 5.63 | 1911-1925 | |
| 6 | Allie Reynolds# | 5.43 | 1942-1954 | |
| 7 | Satchel Paige | 5.13 | 1927-1951 | |
| 8 | Charles Bender* | 5.04 | 1903-1924 | |
| 9 | Curt Simmons# | 4.76 | 1948-1954 | |
| 9 | Max Lanier | 4.76 | 1938-1951 | |
| 11 | Lefty Grove* | 4.60 | 1925-1945 | |
| 12 | Lefty Gomez | 4.53 | 1930-1942 | |
| 13 | Walter Johnson* | 4.46 | 1907-1927 | |
| 14 | Rube Marquard | 4.35 | 1908-1925 | |
| 15 | Johnny Allen | 4.28 | 1932-1942 | |
| 16 | Orval Overall | 4.24 | 1905-1913 | |
| 17 | Bill Hallahan | 4.17 | 1926-1941 | |
| 18 | Dave Brown | 4.15 | 1919-1925 | |
| 18 | Mort Cooper | 4.15 | 1938-1947 | |
| 20 | Barney Morris | 4.04 | 1932-1947 | |
| 21 | Joe Wood | 4.01 | 1908-1922 | |
| 22 | Eddie Plank* | 4.00 | 1901-1917 | |
| 22 | Jeff Tesreau | 4.00 | 1912-1918 | |
| 24 | Deacon Phillippe | 3.86 | 1899-1911 | |
| 25 | Otto Hess | 3.82 | 1902-1914 | |
| 26 | Dutch Leonard | 3.76 | 1913-1925 | |
| 27 | Hank Borowy | 3.71 | 1942-1948 | |
| 28 | Mordecai Brown* | 3.68 | 1903-1916 | |
| 29 | Hal Schumacher | 3.62 | 1931-1947 | |
| 30 | Christy Mathewson* | 3.59 | 1900-1916 | |
| 31 | Carl Hubbell* | 3.58 | 1928-1948 | |
| 32 | Wilbur Cooper | 3.47 | 1912-1926 | |
| 33 | Babe Adams* | 3.46 | 1906-1926 | |
| 34 | Hod Eller | 3.42 | 1917-1920 | |
| 35 | Jack Quinn | 3.25 | 1909-1932 | |
| 36 | Paul Derringer | 3.20 | 1931-1952 | |
| 37 | Babe Ruth* | 3.09 | 1914-1935 | |
| 38 | Jack Pfiester | 2.97 | 1904-1911 | |
| 39 | Spud Chandler | 2.95 | 1937-1952 | |
| 39 | Jesse Tannehill | 2.95 | 1894-1910 | |
| 41 | Sam Streeter | 2.93 | 1921-1936 | |
| 42 | Ed Brandt | 2.81 | 1928-1950 | |
| 43 | Addie Joss* | 2.75 | 1902-1910 | |
| 44 | Bill Doak | 2.72 | 1913-1929 | |
| 45 | Jesse Haines | 2.68 | 1919-1938 | |
| 45 | Cy Young* | 2.68 | 1890-1911 | |
| 47 | Al Hollingsworth | 2.50 | 1935-1947 | |
| 48 | Herb Pennock | 2.41 | 1912-1934 | |
| 49 | Tiny Bonham | 2.40 | 1940-1950 | |
| 49 | Jumbo Brown | 2.40 | 1926-1952 | |
| 51 | Bill Bernhard | 2.10 | 1899-1907 | |
| 52 | Fred Toney | 1.97 | 1914-1923 | |
| 52 | Tom Zachary | 1.97 | 1920-1936 | |
| 54 | Gentry Jessup# | 1.93 | 1940-1954 | |
| 55 | Waite Hoyt | 1.78 | 1919-1944 | |
| 56 | Jakie May | 1.42 | 1918-1932 |
