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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Rube Waddell | 5.82 | 1897-1910 | |
| 2 | Red Ames# | 5.73 | 1903-1916 | |
| 3 | Vean Gregg# | 5.63 | 1911-1916 | |
| 4 | Charles Bender# | 5.10 | 1903-1916 | |
| 5 | Babe Adams# | 4.71 | 1906-1916 | |
| 6 | Orval Overall | 4.24 | 1905-1913 | |
| 7 | Rube Marquard# | 4.04 | 1908-1916 | |
| 8 | Joe Wood# | 4.01 | 1908-1916 | |
| 9 | Eddie Plank# | 4.00 | 1901-1916 | |
| 9 | Jeff Tesreau# | 4.00 | 1912-1916 | |
| 11 | Deacon Phillippe | 3.86 | 1899-1911 | |
| 12 | Otto Hess | 3.82 | 1902-1914 | |
| 13 | Mordecai Brown | 3.68 | 1903-1916 | |
| 14 | Christy Mathewson | 3.59 | 1900-1916 | |
| 15 | Dutch Leonard# | 3.20 | 1913-1916 | |
| 16 | Jack Pfiester | 2.97 | 1904-1911 | |
| 17 | Jesse Tannehill | 2.95 | 1894-1910 | |
| 18 | Addie Joss | 2.75 | 1902-1910 | |
| 19 | Cy Young* | 2.68 | 1890-1911 | |
| 20 | Bill Bernhard | 2.10 | 1899-1907 |
