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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Rube Waddell | 6.32 | 1897-1910 | |
| 2 | Joe Wood# | 5.79 | 1908-1914 | |
| 3 | Walter Johnson# | 5.63 | 1907-1914 | |
| 4 | Vean Gregg# | 5.58 | 1911-1914 | |
| 5 | Hippo Vaughn# | 5.28 | 1909-1914 | |
| 6 | Rube Marquard# | 5.14 | 1908-1914 | |
| 6 | Charles Bender# | 5.14 | 1903-1914 | |
| 8 | Dutch Leonard# | 5.11 | 1913-1914 | |
| 8 | Cy Seymour | 5.11 | 1896-1913 | |
| 10 | Harry Krause | 5.07 | 1908-1911 | |
| 10 | Willie Mitchell# | 5.07 | 1909-1914 | |
| 12 | Red Ames# | 5.02 | 1903-1914 | |
| 13 | Jeff Tesreau# | 5.01 | 1912-1914 | |
| 14 | Frank Lange | 5.00 | 1910-1913 | |
| 15 | Jose Mendez# | 4.83 | 1907-1914 | |
| 16 | Orval Overall | 4.80 | 1905-1913 | |
| 17 | Ed Walsh# | 4.77 | 1904-1914 | |
| 18 | Doc Ayers# | 4.76 | 1913-1914 | |
| 19 | Jack Coombs# | 4.74 | 1906-1914 | |
| 19 | Christy Mathewson# | 4.74 | 1900-1914 | |
| 21 | Heinie Berger | 4.72 | 1907-1910 | |
| 22 | Jim Scott# | 4.70 | 1909-1914 | |
| 23 | Amos Rusie | 4.61 | 1889-1901 | |
| 24 | Cy Falkenberg# | 4.60 | 1904-1914 | |
| 24 | Sam Frock | 4.60 | 1907-1911 | |
| 26 | Eddie Plank# | 4.59 | 1901-1914 | |
| 27 | Grover Cleveland Alexander# | 4.58 | 1911-1914 | |
| 28 | Russ Ford | 4.56 | 1909-1913 | |
| 29 | Claude Hendrix# | 4.55 | 1911-1914 | |
| 30 | Tom Hughes | 4.52 | 1900-1913 | |
| 30 | Rube Benton# | 4.52 | 1911-1914 | |
| 32 | Jimmy Dygert | 4.51 | 1905-1910 | |
| 33 | George Kahler | 4.47 | 1910-1913 | |
| 34 | Ray Caldwell# | 4.44 | 1910-1914 | |
| 34 | Tom Seaton# | 4.44 | 1912-1914 | |
| 36 | Hugh Bedient | 4.42 | 1912-1914 | |
| 37 | Bill Donovan# | 4.41 | 1898-1914 | |
| 38 | Buck O'Brien | 4.38 | 1911-1913 | |
| 39 | Joe Williams# | 4.37 | 1907-1914 | |
| 39 | Bill Steen# | 4.37 | 1912-1914 | |
| 41 | Lefty Tyler# | 4.35 | 1910-1914 | |
| 42 | Bob Groom# | 4.30 | 1909-1914 | |
| 43 | Charley Hall# | 4.29 | 1906-1913 | |
| 44 | Fred Glade | 4.28 | 1903-1907 | |
| 44 | Earl Moore | 4.28 | 1901-1913 | |
| 46 | Bob Shawkey# | 4.26 | 1913-1914 | |
| 46 | Doc White | 4.26 | 1901-1912 | |
| 48 | Jake Weimer | 4.24 | 1903-1909 | |
| 49 | Nap Rucker# | 4.21 | 1907-1914 | |
| 50 | George Pearce# | 4.19 | 1912-1914 | |
| 51 | Joe Benz# | 4.14 | 1911-1914 | |
| 52 | Noodles Hahn | 4.12 | 1899-1906 | |
| 52 | Eddie Cicotte# | 4.12 | 1906-1914 | |
| 54 | Hooks Wiltse | 4.11 | 1904-1914 | |
| 54 | Frank Smith | 4.11 | 1904-1911 | |
| 54 | Bob Wicker | 4.11 | 1901-1906 | |
| 57 | Jack Pfiester | 4.10 | 1904-1911 | |
| 57 | Frank Wickware# | 4.10 | 1910-1914 | |
| 59 | Hooks Dauss# | 4.08 | 1912-1914 | |
| 60 | Tom Hughes# | 4.04 | 1906-1914 | |
| 61 | Slow Joe Doyle | 4.03 | 1906-1909 | |
| 61 | John Donaldson# | 4.03 | 1913-1914 | |
| 63 | Ed Reulbach# | 4.02 | 1905-1914 | |
| 64 | Bob Ewing | 4.00 | 1902-1910 | |
| 65 | Pat Ragan# | 3.99 | 1909-1914 | |
| 66 | Bill Lindsay | 3.97 | 1909-1914 | |
| 67 | Bugs Raymond | 3.96 | 1904-1910 | |
| 68 | Joe Lake | 3.94 | 1908-1913 | |
| 69 | Glenn Liebhardt | 3.91 | 1906-1909 | |
| 69 | Doc McJames | 3.91 | 1895-1901 | |
| 71 | Elmer Smith | 3.90 | 1886-1901 | |
| 71 | Bill Doak# | 3.90 | 1913-1914 | |
| 73 | Bill James# | 3.89 | 1913-1914 | |
| 73 | Earl Hamilton# | 3.89 | 1911-1914 | |
| 75 | Ray Collins# | 3.88 | 1909-1914 | |
| 75 | Rube Vickers | 3.88 | 1902-1909 | |
| 77 | Cy Morgan | 3.87 | 1904-1912 | |
| 77 | Howie Camnitz | 3.87 | 1904-1913 | |
| 79 | George Mullin | 3.86 | 1902-1913 | |
| 80 | Dixie Walker | 3.85 | 1909-1912 | |
| 81 | Happy Townsend | 3.82 | 1901-1906 | |
| 82 | Johnny Lush | 3.81 | 1904-1910 | |
| 82 | Jack Quinn# | 3.81 | 1909-1914 | |
| 84 | Otto Hess# | 3.78 | 1902-1914 | |
| 85 | Mordecai Brown# | 3.77 | 1903-1912 | |
| 85 | Buttons Briggs | 3.77 | 1896-1905 | |
| 87 | Ned Garvin | 3.76 | 1896-1904 | |
| 87 | Art Fromme# | 3.76 | 1906-1914 | |
| 89 | Jack Chesbro | 3.74 | 1899-1909 | |
| 89 | Rube Foster# | 3.74 | 1902-1914 | |
| 91 | Dummy Taylor | 3.72 | 1900-1908 | |
| 92 | Ad Brennan# | 3.71 | 1910-1914 | |
| 93 | Ed Doheny | 3.70 | 1895-1903 | |
| 94 | Joe Harris | 3.68 | 1905-1907 | |
| 95 | George Van Haltren | 3.67 | 1887-1903 | |
| 95 | Larry Cheney# | 3.67 | 1911-1914 | |
| 97 | Reb Russell# | 3.66 | 1913-1914 | |
| 97 | Norwood Gibson | 3.66 | 1903-1906 | |
| 99 | Roy Witherup | 3.64 | 1906-1909 | |
| 99 | Doc Newton | 3.64 | 1900-1909 |
