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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Joe Williams* | 361 | 1907-1930 | |
| 2 | Cy Young* | 356 | 1890-1911 | |
| 3 | Luis Tiant Sr. | 355 | 1926-1951 | |
| 4 | Bill Foster* | 319 | 1923-1949 | |
| 5 | Eppa Rixey | 315 | 1912-1933 | |
| 6 | Henry McHenry# | 312 | 1931-1954 | |
| 7 | Ted Trent | 309 | 1927-1949 | |
| 8 | Walter Johnson* | 306 | 1907-1927 | |
| 8 | Satchel Paige | 306 | 1927-1951 | |
| 10 | Leroy Matlock | 300 | 1929-1952 | |
| 11 | Red Ruffing | 293 | 1924-1946 | |
| 12 | Paul Derringer | 292 | 1931-1952 | |
| 13 | Larry French | 284 | 1929-1953 | |
| 14 | Grover Cleveland Alexander* | 277 | 1911-1930 | |
| 14 | Eddie Plank* | 277 | 1901-1917 | |
| 16 | Jack Quinn | 272 | 1909-1932 | |
| 17 | Ray Brown | 267 | 1931-1953 | |
| 17 | Vic Willis | 267 | 1898-1910 | |
| 19 | Kid Nichols* | 265 | 1890-1906 | |
| 20 | Andy Cooper | 262 | 1920-1942 | |
| 21 | Bill Holland | 253 | 1919-1941 | |
| 22 | Phil Cockrell | 249 | 1918-1934 | |
| 23 | Roy Partlow# | 247 | 1934-1954 | |
| 24 | Burleigh Grimes | 245 | 1916-1934 | |
| 24 | Jose Mendez* | 245 | 1907-1926 | |
| 26 | Martin Dihigo | 244 | 1924-1946 | |
| 26 | Dick Redding | 244 | 1911-1931 | |
| 28 | Hilton Smith | 242 | 1932-1952 | |
| 29 | Harry Salmon | 239 | 1920-1935 | |
| 30 | Terris McDuffie | 238 | 1930-1950 | |
| 31 | Roosevelt Davis | 237 | 1924-1950 | |
| 32 | Jack Powell | 236 | 1897-1912 | |
| 33 | Leon Day# | 232 | 1935-1954 | |
| 34 | Gus Weyhing | 231 | 1887-1901 | |
| 35 | Barney Brown | 227 | 1931-1952 | |
| 35 | Eddie Cicotte* | 227 | 1906-1923 | |
| 37 | Red Ames* | 225 | 1903-1919 | |
| 37 | Bob Feller# | 225 | 1936-1954 | |
| 37 | Lefty Grove* | 225 | 1925-1945 | |
| 40 | William Bell | 217 | 1923-1942 | |
| 41 | Rube Benton | 215 | 1911-1925 | |
| 42 | Carl Hubbell* | 214 | 1928-1948 | |
| 43 | Tex Carleton | 212 | 1932-1951 | |
| 44 | Rube Marquard | 211 | 1908-1925 | |
| 45 | Fritz Ostermueller | 209 | 1934-1952 | |
| 46 | Red Faber | 208 | 1914-1932 | |
| 47 | Bill Donovan | 207 | 1898-1918 | |
| 48 | Lee Grissom | 206 | 1934-1953 | |
| 49 | Bill Byrd | 205 | 1932-1951 | |
| 49 | Claude Passeau | 205 | 1935-1954 | |
| 51 | Tommy Bridges | 202 | 1930-1944 | |
| 51 | Bill Doak | 202 | 1913-1929 | |
| 51 | Van Mungo# | 202 | 1931-1954 | |
| 54 | Schoolboy Rowe# | 201 | 1933-1954 | |
| 55 | Dolf Luque | 200 | 1914-1935 | |
| 56 | Earl Whitehill | 199 | 1923-1940 | |
| 57 | Roy Welmaker | 198 | 1933-1952 | |
| 58 | Charles Bender* | 197 | 1903-1924 | |
| 58 | Herb Pennock | 197 | 1912-1934 | |
| 60 | Webster McDonald | 196 | 1922-1940 | |
| 61 | Waite Hoyt | 195 | 1919-1944 | |
| 62 | Red Donahue | 194 | 1893-1906 | |
| 63 | Dutch Leonard | 192 | 1913-1925 | |
| 64 | Joe McGinnity | 191 | 1899-1908 | |
| 64 | Al Orth | 191 | 1895-1909 | |
| 66 | Clark Griffith | 189 | 1891-1911 | |
| 66 | Mel Harder# | 189 | 1929-1954 | |
| 66 | Porter Moss# | 189 | 1932-1954 | |
| 69 | Bob Shawkey | 188 | 1913-1927 | |
| 70 | Sam Jones | 187 | 1916-1935 | |
| 71 | Dutch Leonard | 186 | 1933-1954 | |
| 71 | Hippo Vaughn | 186 | 1909-1921 | |
| 73 | Christy Mathewson* | 184 | 1900-1916 | |
| 74 | Pink Hawley | 183 | 1892-1901 | |
| 75 | Cy Falkenberg | 179 | 1904-1917 | |
| 76 | Mordecai Brown* | 176 | 1903-1916 | |
| 76 | Amos Rusie | 176 | 1889-1901 | |
| 78 | Willie Mitchell | 174 | 1909-1919 | |
| 79 | Ed Brandt | 173 | 1928-1950 | |
| 80 | Barney Morris | 172 | 1932-1947 | |
| 80 | Bobo Newsom | 172 | 1929-1948 | |
| 80 | Barney Pelty | 172 | 1903-1912 | |
| 80 | Dazzy Vance | 172 | 1921-1935 | |
| 84 | Willis Hudlin | 171 | 1926-1939 | |
| 84 | Carl Mays | 171 | 1915-1929 | |
| 86 | Babe Adams* | 169 | 1906-1926 | |
| 86 | Ed Walsh* | 169 | 1904-1914 | |
| 88 | Ted Breitenstein | 168 | 1891-1901 | |
| 88 | Bert Cunningham | 168 | 1887-1901 | |
| 88 | Rube Waddell* | 168 | 1897-1910 | |
| 91 | Bill Dinneen | 167 | 1898-1909 | |
| 92 | Brickyard Kennedy | 166 | 1892-1903 | |
| 93 | Guy Morton | 165 | 1914-1924 | |
| 93 | Slim Sallee | 165 | 1908-1921 | |
| 95 | Andy Porter# | 164 | 1932-1954 | |
| 96 | Nap Rucker | 163 | 1907-1916 | |
| 97 | Denny Galehouse | 162 | 1934-1948 | |
| 97 | Bullet Rogan* | 162 | 1915-1934 | |
| 97 | Johnny Vander Meer | 162 | 1937-1950 | |
| 100 | Stan Coveleski | 161 | 1915-1928 |
