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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | RBI | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Jimmie Foxx* | 168 | 1937 | |
| 2 | Lou Gehrig* | 162 | 1936 | |
| 3 | Lou Gehrig* | 160 | 1929 | |
| 4 | Jim Bottomley | 159 | 1928 | |
| 5 | John Beckwith* | 158 | 1930 | |
| 5 | Johnny Mize# | 158 | 1946 | |
| 7 | Hank Greenberg# | 155 | 1938 | |
| 8 | Hal Chase | 153 | 1916 | |
| 9 | Lou Gehrig* | 152 | 1930 | |
| 9 | Harry Heilmann* | 152 | 1927 | |
| 11 | Zeke Bonura | 151 | 1937 | |
| 12 | Jim Bottomley | 150 | 1924 | |
| 13 | Lou Gehrig* | 149 | 1934 | |
| 13 | Jimmie Foxx* | 149 | 1929 | |
| 15 | Joe Hauser | 145 | 1924 | |
| 16 | Harry Heilmann* | 144 | 1921 | |
| 17 | Jimmie Foxx* | 143 | 1932 | |
| 18 | Jimmie Foxx* | 141 | 1935 | |
| 18 | Sam Crawford* | 141 | 1912 | |
| 20 | Hank Greenberg# | 140 | 1935 | |
| 21 | Jim Bottomley | 139 | 1925 | |
| 21 | Charlie Hickman | 139 | 1905 | |
| 21 | Lou Gehrig* | 139 | 1935 | |
| 21 | Lou Gehrig* | 139 | 1927 | |
| 25 | Hank Greenberg# | 138 | 1936 | |
| 25 | Hal Trosky | 138 | 1936 | |
| 27 | Lou Gehrig* | 137 | 1932 | |
| 27 | Dale Alexander | 137 | 1929 | |
| 27 | John Beckwith* | 137 | 1931 | |
| 30 | Jim Bottomley | 136 | 1929 | |
| 30 | George Crowe# | 136 | 1948 | |
| 30 | Ed Delahanty* | 136 | 1903 | |
| 30 | Johnny Mize# | 136 | 1948 | |
| 34 | Mickey Vernon# | 135 | 1953 | |
| 34 | Jimmie Foxx* | 135 | 1938 | |
| 34 | Jimmie Foxx* | 135 | 1940 | |
| 37 | Babe Herman | 134 | 1930 | |
| 38 | Jimmie Foxx* | 133 | 1936 | |
| 39 | Sid Gordon# | 131 | 1950 | |
| 39 | Jimmie Foxx* | 131 | 1931 | |
| 41 | Jack Fournier | 130 | 1923 | |
| 41 | Luke Easter# | 130 | 1938 | |
| 41 | Lou Gehrig* | 130 | 1928 | |
| 41 | John Beckwith* | 130 | 1924 | |
| 41 | Zeke Bonura | 130 | 1936 | |
| 46 | Lou Gehrig* | 129 | 1938 | |
| 46 | Jimmie Foxx* | 129 | 1934 | |
| 46 | Ted Kluszewski# | 129 | 1954 | |
| 49 | Zeke Bonura | 128 | 1934 | |
| 49 | Rudy York | 128 | 1940 | |
| 49 | Dan Brouthers* | 128 | 1894 | |
| 52 | Nap Lajoie* | 127 | 1897 | |
| 52 | Mickey Vernon# | 127 | 1954 | |
| 54 | Jim Bottomley | 126 | 1923 | |
| 54 | Joe Harris | 126 | 1925 | |
| 54 | Lou Gehrig* | 126 | 1933 | |
| 57 | Luke Easter# | 125 | 1937 | |
| 57 | Jack Fournier | 125 | 1925 | |
| 57 | Lou Gehrig* | 125 | 1931 | |
| 57 | Jimmie Foxx* | 125 | 1930 | |
| 57 | Hank Greenberg# | 125 | 1939 | |
| 57 | John Beckwith* | 125 | 1923 | |
| 57 | Jimmie Foxx* | 125 | 1939 | |
| 57 | John Beckwith* | 125 | 1925 | |
| 65 | Ripper Collins | 124 | 1935 | |
| 65 | Rudy York | 124 | 1941 | |
| 65 | Dan Brouthers* | 124 | 1892 | |
| 65 | Jimmie Foxx* | 124 | 1933 | |
| 65 | Johnny Mize# | 124 | 1947 | |
| 65 | Jim Bottomley | 124 | 1927 | |
| 65 | Ted Kluszewski# | 124 | 1953 | |
| 72 | Buck Leonard | 123 | 1939 | |
| 72 | Fred Merkle | 123 | 1911 | |
| 72 | Johnny Mize# | 123 | 1942 | |
| 72 | Jake Beckley | 123 | 1890 | |
| 72 | Fred Merkle | 123 | 1912 | |
| 72 | Red Kress | 123 | 1930 | |
| 78 | Ed Morgan | 122 | 1930 | |
| 78 | Don Hurst | 122 | 1929 | |
| 78 | Johnny Mize# | 122 | 1949 | |
| 81 | Dolph Camilli | 121 | 1936 | |
| 81 | Fred Merkle | 121 | 1910 | |
| 81 | Bill Terry | 121 | 1929 | |
| 81 | Paul Waner | 121 | 1928 | |
| 81 | Harry Heilmann* | 121 | 1920 | |
| 86 | Jake Beckley | 120 | 1894 | |
| 86 | George Crowe# | 120 | 1954 | |
| 86 | George Grantham | 120 | 1929 | |
| 89 | John Beckwith* | 119 | 1921 | |
| 89 | Lou Gehrig* | 119 | 1926 | |
| 89 | Jimmie Foxx* | 119 | 1927 | |
| 89 | Del Bissonette | 119 | 1929 | |
| 93 | Dan Brouthers* | 118 | 1889 | |
| 93 | Buck Freeman | 118 | 1902 | |
| 93 | Zeke Bonura | 118 | 1938 | |
| 96 | Gil Hodges# | 117 | 1953 | |
| 96 | Hank Greenberg# | 117 | 1937 | |
| 96 | Sid Gordon# | 117 | 1951 | |
| 96 | Ralph Kiner# | 117 | 1950 | |
| 100 | Stan Musial# | 116 | 1950 |
