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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Charles Bender# | 62 | 1903-1916 | |
| 2 | Rube Waddell | 56 | 1897-1910 | |
| 3 | Red Ames# | 35 | 1903-1916 | |
| 4 | Christy Mathewson | 32 | 1900-1916 | |
| 5 | Vean Gregg# | 29 | 1911-1916 | |
| 6 | Rube Marquard# | 25 | 1908-1916 | |
| 7 | Mordecai Brown | 24 | 1903-1916 | |
| 8 | Cy Young* | 22 | 1890-1911 | |
| 9 | Dutch Leonard# | 21 | 1913-1916 | |
| 9 | Jesse Tannehill | 21 | 1894-1910 | |
| 11 | Jeff Tesreau# | 20 | 1912-1916 | |
| 12 | Babe Adams# | 19 | 1906-1916 | |
| 13 | Tom Hughes# | 18 | 1906-1916 | |
| 14 | Jack Coombs# | 16 | 1906-1916 | |
| 14 | Orval Overall | 16 | 1905-1913 | |
| 14 | Eddie Plank# | 16 | 1901-1916 | |
| 17 | Joe Wood# | 15 | 1908-1916 | |
| 18 | Deacon Phillippe | 14 | 1899-1911 | |
| 19 | Claude Hendrix# | 13 | 1911-1916 | |
| 19 | Otto Hess | 13 | 1902-1914 | |
| 19 | Kid Nichols* | 13 | 1890-1906 | |
| 19 | Babe Ruth# | 13 | 1914-1916 | |
| 23 | Jack Pfiester | 12 | 1904-1911 | |
| 24 | Bill Donovan# | 11 | 1898-1916 | |
| 24 | Addie Joss | 11 | 1902-1910 | |
| 24 | George McConnell | 11 | 1912-1916 | |
| 24 | Doc White | 11 | 1901-1912 | |
| 28 | Tom Hughes | 10 | 1900-1913 | |
| 29 | Frank Smith | 9 | 1904-1911 | |
| 29 | Joe Williams# | 9 | 1907-1916 | |
| 29 | Hooks Wiltse | 9 | 1904-1914 | |
| 32 | Bill Bernhard | 8 | 1899-1907 | |
| 32 | Ferdie Schupp# | 8 | 1916-1916 | |
| 34 | Jack Chesbro | 7 | 1899-1909 | |
| 34 | Harry Krause | 7 | 1908-1911 | |
| 34 | George McQuillan# | 7 | 1907-1916 | |
| 34 | Earl Moore | 7 | 1901-1913 | |
| 38 | Fred Anderson# | 6 | 1909-1916 | |
| 38 | Weldon Henley | 6 | 1903-1907 | |
| 38 | Joe Lake | 6 | 1908-1913 | |
| 38 | Frank Lange | 6 | 1910-1913 | |
| 38 | Lefty Leifield# | 6 | 1905-1913 | |
| 38 | Charlie Smith | 6 | 1903-1914 | |
| 38 | George Winter | 6 | 1901-1908 | |
| 45 | George Mullin | 5 | 1902-1913 | |
| 46 | Russ Ford | 4 | 1909-1913 | |
| 46 | Marty McHale | 4 | 1913-1916 | |
| 46 | Jimmy Ryan | 4 | 1885-1903 | |
| 49 | Eddie Cicotte# | 3 | 1906-1916 | |
| 49 | Win Kellum | 3 | 1901-1905 | |
| 49 | Bill Phyle | 3 | 1898-1906 | |
| 49 | George Prentiss | 3 | 1901-1902 | |
| 49 | Hank Robinson# | 3 | 1911-1916 | |
| 49 | Dummy Taylor | 3 | 1900-1908 | |
| 55 | Al Demaree# | 2 | 1912-1916 | |
| 55 | George Ferguson | 2 | 1906-1910 | |
| 55 | Norwood Gibson | 2 | 1903-1906 | |
| 55 | Jock Menefee | 2 | 1892-1903 | |
| 55 | Ernie Shore# | 2 | 1914-1916 | |
| 60 | Nick Altrock# | 1 | 1898-1916 | |
| 60 | Ray Collins | 1 | 1909-1915 | |
| 60 | Frank Corridon | 1 | 1906-1909 | |
| 60 | George Cuppy | 1 | 1892-1901 | |
| 60 | Gus Dorner | 1 | 1902-1909 | |
| 60 | Cy Falkenberg# | 1 | 1904-1915 | |
| 60 | Frank Foreman | 1 | 1884-1902 | |
| 60 | Rube Foster# | 1 | 1913-1916 | |
| 60 | Ed Killian | 1 | 1903-1910 | |
| 60 | Ted Lewis | 1 | 1896-1901 | |
| 60 | Carl Mays# | 1 | 1915-1916 | |
| 60 | Jack Rowan | 1 | 1906-1914 | |
| 60 | Ed Siever | 1 | 1901-1908 | |
| 73 | Joe Bush# | 0 | 1912-1916 | |
| 73 | Sam Leever | 0 | 1898-1909 | |
| 73 | Fred Mitchell | 0 | 1902-1911 | |
| 73 | Ed Reulbach# | 0 | 1905-1916 | |
| 73 | Paul Strand# | 0 | 1913-1915 | |
| 73 | Dave Williams | 0 | 1902-1902 | |
| 73 | Snake Wiltse | 0 | 1901-1903 |
