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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Charles Bender* | 64 | 1903-1924 | |
| 2 | Lefty Gomez | 59 | 1930-1942 | |
| 3 | Rube Waddell* | 56 | 1897-1910 | |
| 4 | Johnny Allen | 51 | 1932-1942 | |
| 5 | Dutch Leonard | 46 | 1913-1925 | |
| 6 | Ed Brandt | 42 | 1928-1950 | |
| 7 | Carl Hubbell* | 40 | 1928-1948 | |
| 8 | Van Mungo# | 39 | 1931-1954 | |
| 9 | Allie Reynolds# | 37 | 1942-1954 | |
| 10 | Spud Chandler | 36 | 1937-1952 | |
| 10 | Walter Johnson* | 36 | 1907-1927 | |
| 10 | Curt Simmons# | 36 | 1948-1954 | |
| 13 | Red Ames* | 35 | 1903-1919 | |
| 13 | Rube Marquard | 35 | 1908-1925 | |
| 15 | Max Lanier | 34 | 1938-1951 | |
| 16 | Christy Mathewson* | 32 | 1900-1916 | |
| 17 | Vean Gregg | 29 | 1911-1925 | |
| 17 | Jack Quinn | 29 | 1909-1932 | |
| 19 | Mordecai Brown* | 24 | 1903-1916 | |
| 20 | Satchel Paige | 23 | 1927-1951 | |
| 21 | Cy Young* | 22 | 1890-1911 | |
| 22 | Bill Hallahan | 21 | 1926-1941 | |
| 22 | Charley Root | 21 | 1923-1940 | |
| 22 | Jesse Tannehill | 21 | 1894-1910 | |
| 25 | Babe Adams* | 20 | 1906-1926 | |
| 25 | Mort Cooper | 20 | 1938-1947 | |
| 25 | Ad Lankford | 20 | 1913-1920 | |
| 25 | Hal Schumacher | 20 | 1931-1947 | |
| 25 | Jeff Tesreau | 20 | 1912-1918 | |
| 30 | Hod Eller | 19 | 1917-1920 | |
| 30 | Babe Ruth* | 19 | 1914-1935 | |
| 30 | Sam Streeter | 19 | 1921-1936 | |
| 33 | Wilbur Cooper | 18 | 1912-1926 | |
| 33 | Tom Hughes | 18 | 1906-1917 | |
| 35 | Jack Coombs | 16 | 1906-1916 | |
| 35 | Paul Derringer | 16 | 1931-1952 | |
| 35 | Lefty Grove* | 16 | 1925-1945 | |
| 35 | Barney Morris | 16 | 1932-1947 | |
| 35 | Orval Overall | 16 | 1905-1913 | |
| 35 | Eddie Plank* | 16 | 1901-1917 | |
| 41 | Jesse Haines | 15 | 1919-1938 | |
| 41 | Sal Maglie# | 15 | 1945-1954 | |
| 41 | Cliff Melton | 15 | 1937-1943 | |
| 41 | Joe Wood | 15 | 1908-1922 | |
| 45 | Hank Borowy | 14 | 1942-1948 | |
| 45 | Dave Brown | 14 | 1919-1925 | |
| 45 | Deacon Phillippe | 14 | 1899-1911 | |
| 45 | Billy Pierce# | 14 | 1949-1954 | |
| 49 | Harry Brecheen# | 13 | 1942-1954 | |
| 49 | Claude Hendrix | 13 | 1911-1920 | |
| 49 | Otto Hess | 13 | 1902-1914 | |
| 49 | Ed Morris | 13 | 1922-1931 | |
| 49 | Kid Nichols* | 13 | 1890-1906 | |
| 54 | Tiny Bonham | 12 | 1940-1950 | |
| 54 | Bill Doak | 12 | 1913-1929 | |
| 54 | Lee Grissom | 12 | 1934-1953 | |
| 54 | Jack Pfiester | 12 | 1904-1911 | |
| 58 | Jumbo Brown | 11 | 1926-1952 | |
| 58 | Bill Donovan | 11 | 1898-1918 | |
| 58 | Red Faber | 11 | 1914-1932 | |
| 58 | Al Hollingsworth | 11 | 1935-1947 | |
| 58 | Addie Joss* | 11 | 1902-1910 | |
| 58 | George McConnell | 11 | 1912-1916 | |
| 58 | Jose Mendez* | 11 | 1907-1926 | |
| 58 | Vinegar Bend Mizell# | 11 | 1952-1954 | |
| 58 | Eppa Rixey | 11 | 1912-1933 | |
| 58 | Jim Weaver | 11 | 1928-1949 | |
| 58 | Doc White | 11 | 1901-1912 | |
| 69 | Sheriff Blake | 10 | 1920-1938 | |
| 69 | Ray Brown | 10 | 1931-1953 | |
| 69 | Lino Donoso# | 10 | 1946-1954 | |
| 69 | Waite Hoyt | 10 | 1919-1944 | |
| 69 | Tom Hughes | 10 | 1900-1913 | |
| 74 | Grover Cleveland Alexander* | 9 | 1911-1930 | |
| 74 | Fred Anderson | 9 | 1909-1918 | |
| 74 | Bill Bevens# | 9 | 1945-1954 | |
| 74 | Eddie Cicotte* | 9 | 1906-1923 | |
| 74 | Bill Gatewood | 9 | 1906-1927 | |
| 74 | Jack Harshman# | 9 | 1953-1954 | |
| 74 | Sam Jones | 9 | 1916-1935 | |
| 74 | Carl Mays | 9 | 1915-1929 | |
| 74 | Red Munger | 9 | 1943-1949 | |
| 74 | Herb Pennock | 9 | 1912-1934 | |
| 74 | George Pipgras | 9 | 1926-1934 | |
| 74 | Rip Sewell | 9 | 1937-1944 | |
| 74 | Bob Shawkey | 9 | 1913-1927 | |
| 74 | Frank Smith | 9 | 1904-1911 | |
| 74 | Virgil Trucks# | 9 | 1941-1954 | |
| 74 | Joe Williams* | 9 | 1907-1930 | |
| 74 | Hooks Wiltse | 9 | 1904-1914 | |
| 74 | Nip Winters | 9 | 1921-1932 | |
| 92 | Johnny Beazley | 8 | 1941-1943 | |
| 92 | Bill Bernhard | 8 | 1899-1907 | |
| 92 | Karl Drews# | 8 | 1951-1953 | |
| 92 | Burleigh Grimes | 8 | 1916-1934 | |
| 92 | Bill Lee | 8 | 1934-1946 | |
| 92 | Webster McDonald | 8 | 1922-1940 | |
| 92 | Jeff Pfeffer | 8 | 1913-1924 | |
| 92 | Nels Potter# | 8 | 1943-1954 | |
| 92 | Ken Raffensberger | 8 | 1939-1953 |
