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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Ed Brandt | 134.0 | 1928-1950 | |
| 2 | Lefty Gomez | 117.0 | 1930-1942 | |
| 3 | Charles Bender* | 114.0 | 1903-1924 | |
| 4 | Dutch Leonard | 110.0 | 1913-1925 | |
| 5 | Spud Chandler | 109.0 | 1937-1952 | |
| 6 | Johnny Allen | 107.0 | 1932-1942 | |
| 7 | Carl Hubbell* | 100.0 | 1928-1948 | |
| 8 | Rube Waddell* | 86.0 | 1897-1910 | |
| 9 | Christy Mathewson* | 80.0 | 1900-1916 | |
| 9 | Jack Quinn | 80.0 | 1909-1932 | |
| 11 | Cy Young* | 74.0 | 1890-1911 | |
| 12 | Walter Johnson* | 72.0 | 1907-1927 | |
| 12 | Rube Marquard | 72.0 | 1908-1925 | |
| 14 | Curt Simmons# | 68.0 | 1948-1954 | |
| 15 | Max Lanier | 64.0 | 1938-1951 | |
| 15 | Jesse Tannehill | 64.0 | 1894-1910 | |
| 17 | Allie Reynolds# | 61.0 | 1942-1954 | |
| 18 | Mordecai Brown* | 58.0 | 1903-1916 | |
| 18 | Sam Streeter | 58.0 | 1921-1936 | |
| 20 | Babe Ruth* | 55.0 | 1914-1935 | |
| 20 | Red Ames* | 55.0 | 1903-1919 | |
| 22 | Babe Adams* | 52.0 | 1906-1926 | |
| 23 | Van Mungo# | 51.0 | 1931-1954 | |
| 24 | Waite Hoyt | 50.0 | 1919-1944 | |
| 24 | Jesse Haines | 50.0 | 1919-1938 | |
| 24 | Hod Eller | 50.0 | 1917-1920 | |
| 27 | Hal Schumacher | 49.0 | 1931-1947 | |
| 28 | Wilbur Cooper | 46.0 | 1912-1926 | |
| 28 | Vean Gregg | 46.0 | 1911-1925 | |
| 30 | Bill Hallahan | 45.0 | 1926-1941 | |
| 30 | Tiny Bonham | 45.0 | 1940-1950 | |
| 30 | Paul Derringer | 45.0 | 1931-1952 | |
| 30 | Jeff Tesreau | 45.0 | 1912-1918 | |
| 34 | Mort Cooper | 43.0 | 1938-1947 | |
| 35 | Jumbo Brown | 41.0 | 1926-1952 | |
| 36 | Satchel Paige | 40.0 | 1927-1951 | |
| 37 | Bill Doak | 39.0 | 1913-1929 | |
| 37 | Al Hollingsworth | 39.0 | 1935-1947 | |
| 39 | Jack Pfiester | 36.0 | 1904-1911 | |
| 39 | Addie Joss* | 36.0 | 1902-1910 | |
| 39 | Eddie Plank* | 36.0 | 1901-1917 | |
| 42 | Barney Morris | 35.0 | 1932-1947 | |
| 43 | Bill Bernhard | 34.0 | 1899-1907 | |
| 43 | Hank Borowy | 34.0 | 1942-1948 | |
| 43 | Orval Overall | 34.0 | 1905-1913 | |
| 46 | Herb Pennock | 33.0 | 1912-1934 | |
| 46 | Joe Wood | 33.0 | 1908-1922 | |
| 48 | Gentry Jessup# | 32.0 | 1940-1954 | |
| 48 | Deacon Phillippe | 32.0 | 1899-1911 | |
| 48 | Fred Toney | 32.0 | 1914-1923 | |
| 48 | Tom Zachary | 32.0 | 1920-1936 | |
| 52 | Jakie May | 31.0 | 1918-1932 | |
| 52 | Lefty Grove* | 31.0 | 1925-1945 | |
| 52 | Charley Root | 31.0 | 1923-1940 | |
| 55 | Otto Hess | 30.0 | 1902-1914 | |
| 55 | Dave Brown | 30.0 | 1919-1925 | |
| 57 | Red Faber | 29.0 | 1914-1932 | |
| 57 | Doc White | 29.0 | 1901-1912 | |
| 57 | Hilton Smith | 29.0 | 1932-1952 | |
| 57 | Hooks Wiltse | 29.0 | 1904-1914 | |
| 61 | Sal Maglie# | 28.0 | 1945-1954 | |
| 61 | Sam Jones | 28.0 | 1916-1935 | |
| 63 | Jack Coombs | 27.0 | 1906-1916 | |
| 63 | Ed Morris | 27.0 | 1922-1931 | |
| 65 | Bill Bevens# | 26.0 | 1945-1954 | |
| 65 | Red Munger | 26.0 | 1943-1949 | |
| 65 | Harry Brecheen# | 26.0 | 1942-1954 | |
| 65 | Ray Brown | 26.0 | 1931-1953 | |
| 65 | George McConnell | 26.0 | 1912-1916 | |
| 65 | Jack Chesbro | 26.0 | 1899-1909 | |
| 65 | Jim Weaver | 26.0 | 1928-1949 | |
| 72 | Freddie Fitzsimmons | 25.0 | 1925-1941 | |
| 72 | Claude Hendrix | 25.0 | 1911-1920 | |
| 74 | Carl Mays | 24.0 | 1915-1929 | |
| 74 | Burleigh Grimes | 24.0 | 1916-1934 | |
| 74 | Ad Lankford | 24.0 | 1913-1920 | |
| 74 | Grover Cleveland Alexander* | 24.0 | 1911-1930 | |
| 74 | Fred Anderson | 24.0 | 1909-1918 | |
| 74 | Webster McDonald | 24.0 | 1922-1940 | |
| 80 | Billy Pierce# | 23.0 | 1949-1954 | |
| 80 | Monty Stratton# | 23.0 | 1934-1954 | |
| 80 | Eppa Rixey | 23.0 | 1912-1933 | |
| 83 | Dutch Leonard | 22.0 | 1933-1954 | |
| 83 | William Bell | 22.0 | 1923-1942 | |
| 83 | George Winter | 22.0 | 1901-1908 | |
| 86 | Dizzy Dean | 21.0 | 1930-1940 | |
| 86 | Wally Hebert | 21.0 | 1931-1952 | |
| 86 | Tom Hughes | 21.0 | 1906-1917 | |
| 86 | Connie Marrero | 21.0 | 1950-1953 | |
| 86 | Tommy Thomas | 21.0 | 1926-1936 | |
| 91 | Cliff Melton | 20.0 | 1937-1943 | |
| 91 | Sheriff Blake | 20.0 | 1920-1938 | |
| 91 | Dutch Ruether | 20.0 | 1917-1927 | |
| 91 | Eddie Cicotte* | 20.0 | 1906-1923 | |
| 91 | Harry Krause | 20.0 | 1908-1911 | |
| 91 | Ted Lyons | 20.0 | 1925-1944 | |
| 97 | Jack Bentley | 19.0 | 1914-1926 | |
| 97 | Ferdie Schupp | 19.0 | 1916-1922 | |
| 97 | Urban Shocker | 19.0 | 1916-1928 | |
| 97 | Charlie Smith | 19.0 | 1903-1914 |
