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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Charles Bender# | 62 | 1903-1915 | |
| 2 | Rube Waddell | 56 | 1897-1910 | |
| 3 | Red Ames# | 33 | 1903-1915 | |
| 4 | Christy Mathewson# | 32 | 1900-1915 | |
| 5 | Vean Gregg# | 29 | 1911-1915 | |
| 6 | Rube Marquard# | 25 | 1908-1915 | |
| 7 | Mordecai Brown# | 24 | 1903-1915 | |
| 8 | Cy Young | 22 | 1890-1911 | |
| 9 | Jesse Tannehill | 21 | 1894-1910 | |
| 10 | Babe Adams# | 19 | 1906-1915 | |
| 11 | Jack Coombs# | 16 | 1906-1915 | |
| 11 | Orval Overall | 16 | 1905-1913 | |
| 11 | Eddie Plank# | 16 | 1901-1915 | |
| 11 | Jeff Tesreau# | 16 | 1912-1915 | |
| 15 | Joe Wood# | 15 | 1908-1915 | |
| 16 | Deacon Phillippe | 14 | 1899-1911 | |
| 17 | Claude Hendrix# | 13 | 1911-1915 | |
| 17 | Otto Hess | 13 | 1902-1914 | |
| 17 | Tom Hughes# | 13 | 1906-1915 | |
| 17 | Kid Nichols* | 13 | 1890-1906 | |
| 21 | Dutch Leonard# | 12 | 1913-1915 | |
| 21 | Jack Pfiester | 12 | 1904-1911 | |
| 23 | Bill Donovan# | 11 | 1898-1914 | |
| 23 | Addie Joss | 11 | 1902-1910 | |
| 23 | George McConnell# | 11 | 1912-1915 | |
| 23 | Doc White | 11 | 1901-1912 | |
| 27 | Tom Hughes | 10 | 1900-1913 | |
| 28 | Frank Smith | 9 | 1904-1911 | |
| 28 | Joe Williams# | 9 | 1907-1915 | |
| 28 | Hooks Wiltse | 9 | 1904-1914 | |
| 31 | Bill Bernhard | 8 | 1899-1907 | |
| 32 | Jack Chesbro | 7 | 1899-1909 | |
| 32 | Harry Krause | 7 | 1908-1911 | |
| 32 | George McQuillan# | 7 | 1907-1915 | |
| 32 | Earl Moore | 7 | 1901-1913 | |
| 36 | Weldon Henley | 6 | 1903-1907 | |
| 36 | Joe Lake | 6 | 1908-1913 | |
| 36 | Frank Lange | 6 | 1910-1913 | |
| 36 | Lefty Leifield# | 6 | 1905-1913 | |
| 36 | Babe Ruth# | 6 | 1914-1915 | |
| 36 | Charlie Smith | 6 | 1903-1914 | |
| 36 | George Winter | 6 | 1901-1908 | |
| 43 | George Mullin | 5 | 1902-1913 | |
| 44 | Russ Ford | 4 | 1909-1913 | |
| 44 | Marty McHale# | 4 | 1913-1915 | |
| 44 | Jimmy Ryan | 4 | 1885-1903 | |
| 47 | Eddie Cicotte# | 3 | 1906-1915 | |
| 47 | Win Kellum | 3 | 1901-1905 | |
| 47 | Bill Phyle | 3 | 1898-1906 | |
| 47 | George Prentiss | 3 | 1901-1902 | |
| 47 | Hank Robinson# | 3 | 1911-1915 | |
| 47 | Dummy Taylor | 3 | 1900-1908 | |
| 53 | George Ferguson | 2 | 1906-1910 | |
| 53 | Norwood Gibson | 2 | 1903-1906 | |
| 53 | Jock Menefee | 2 | 1892-1903 | |
| 56 | Nick Altrock# | 1 | 1898-1915 | |
| 56 | Ray Collins | 1 | 1909-1915 | |
| 56 | Frank Corridon | 1 | 1906-1909 | |
| 56 | George Cuppy | 1 | 1892-1901 | |
| 56 | Gus Dorner | 1 | 1902-1909 | |
| 56 | Cy Falkenberg# | 1 | 1904-1915 | |
| 56 | Frank Foreman | 1 | 1884-1902 | |
| 56 | Rube Foster# | 1 | 1913-1915 | |
| 56 | Ed Killian | 1 | 1903-1910 | |
| 56 | Ted Lewis | 1 | 1896-1901 | |
| 56 | Carl Mays# | 1 | 1915-1915 | |
| 56 | Jack Rowan | 1 | 1906-1914 | |
| 56 | Ed Siever | 1 | 1901-1908 | |
| 69 | Fred Anderson# | 0 | 1909-1915 | |
| 69 | Joe Bush# | 0 | 1912-1915 | |
| 69 | Sam Leever | 0 | 1898-1909 | |
| 69 | Fred Mitchell | 0 | 1902-1911 | |
| 69 | Ed Reulbach# | 0 | 1905-1915 | |
| 69 | Paul Strand# | 0 | 1913-1915 | |
| 69 | Dave Williams | 0 | 1902-1902 | |
| 69 | Snake Wiltse | 0 | 1901-1903 |
