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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Charles Bender# | 109.0 | 1903-1915 | |
| 2 | Rube Waddell | 86.0 | 1897-1910 | |
| 3 | Christy Mathewson# | 80.0 | 1900-1915 | |
| 4 | Cy Young | 74.0 | 1890-1911 | |
| 5 | Jesse Tannehill | 64.0 | 1894-1910 | |
| 6 | Mordecai Brown# | 58.0 | 1903-1915 | |
| 7 | Rube Marquard# | 55.0 | 1908-1915 | |
| 8 | Red Ames# | 51.0 | 1903-1915 | |
| 9 | Vean Gregg# | 46.0 | 1911-1915 | |
| 10 | Babe Adams# | 36.0 | 1906-1915 | |
| 10 | Jack Pfiester | 36.0 | 1904-1911 | |
| 10 | Addie Joss | 36.0 | 1902-1910 | |
| 10 | Eddie Plank# | 36.0 | 1901-1915 | |
| 10 | Jeff Tesreau# | 36.0 | 1912-1915 | |
| 15 | Dutch Leonard# | 35.0 | 1913-1915 | |
| 16 | Bill Bernhard | 34.0 | 1899-1907 | |
| 16 | Orval Overall | 34.0 | 1905-1913 | |
| 18 | Joe Wood# | 33.0 | 1908-1915 | |
| 19 | Deacon Phillippe | 32.0 | 1899-1911 | |
| 20 | Otto Hess | 30.0 | 1902-1914 | |
| 21 | Doc White | 29.0 | 1901-1912 | |
| 21 | Hooks Wiltse | 29.0 | 1904-1914 | |
| 23 | Jack Coombs# | 27.0 | 1906-1915 | |
| 24 | George McConnell# | 26.0 | 1912-1915 | |
| 24 | Jack Chesbro | 26.0 | 1899-1909 | |
| 26 | Claude Hendrix# | 25.0 | 1911-1915 | |
| 27 | George Winter | 22.0 | 1901-1908 | |
| 28 | Harry Krause | 20.0 | 1908-1911 | |
| 29 | Charlie Smith | 19.0 | 1903-1914 | |
| 29 | George McQuillan# | 19.0 | 1907-1915 | |
| 31 | Frank Smith | 18.0 | 1904-1911 | |
| 31 | Kid Nichols* | 18.0 | 1890-1906 | |
| 31 | Joe Williams# | 18.0 | 1907-1915 | |
| 34 | Russ Ford | 17.0 | 1909-1913 | |
| 34 | Joe Lake | 17.0 | 1908-1913 | |
| 36 | Bill Donovan# | 16.0 | 1898-1914 | |
| 36 | Weldon Henley | 16.0 | 1903-1907 | |
| 38 | Tom Hughes | 15.0 | 1900-1913 | |
| 38 | George Mullin | 15.0 | 1902-1913 | |
| 40 | Frank Lange | 14.0 | 1910-1913 | |
| 40 | Lefty Leifield# | 14.0 | 1905-1913 | |
| 40 | Earl Moore | 14.0 | 1901-1913 | |
| 43 | Tom Hughes# | 13.0 | 1906-1915 | |
| 44 | Marty McHale# | 12.0 | 1913-1915 | |
| 45 | Hank Robinson# | 10.0 | 1911-1915 | |
| 46 | George Cuppy | 9.0 | 1892-1901 | |
| 46 | Win Kellum | 9.0 | 1901-1905 | |
| 46 | Jock Menefee | 9.0 | 1892-1903 | |
| 46 | Babe Ruth# | 9.0 | 1914-1915 | |
| 46 | Dummy Taylor | 9.0 | 1900-1908 | |
| 51 | Nick Altrock# | 7.0 | 1898-1915 | |
| 52 | Ray Collins | 6.0 | 1909-1915 | |
| 52 | Norwood Gibson | 6.0 | 1903-1906 | |
| 54 | Bill Phyle | 5.0 | 1898-1906 | |
| 54 | George Prentiss | 5.0 | 1901-1902 | |
| 54 | Jimmy Ryan | 5.0 | 1885-1903 | |
| 57 | Eddie Cicotte# | 4.0 | 1906-1915 | |
| 57 | Sam Leever | 4.0 | 1898-1909 | |
| 57 | Cy Falkenberg# | 4.0 | 1904-1915 | |
| 57 | Ed Killian | 4.0 | 1903-1910 | |
| 61 | Dave Williams | 3.0 | 1902-1902 | |
| 61 | Jack Rowan | 3.0 | 1906-1914 | |
| 63 | Joe Bush# | 2.0 | 1912-1915 | |
| 63 | Ted Lewis | 2.0 | 1896-1901 | |
| 63 | Carl Mays# | 2.0 | 1915-1915 | |
| 66 | George Ferguson | 1.0 | 1906-1910 | |
| 66 | Frank Corridon | 1.0 | 1906-1909 | |
| 66 | Rube Foster# | 1.0 | 1913-1915 | |
| 66 | Snake Wiltse | 1.0 | 1901-1903 | |
| 66 | Gus Dorner | 1.0 | 1902-1909 | |
| 66 | Frank Foreman | 1.0 | 1884-1902 | |
| 66 | Fred Mitchell | 1.0 | 1902-1911 | |
| 66 | Ed Reulbach# | 1.0 | 1905-1915 | |
| 66 | Ed Siever | 1.0 | 1901-1908 | |
| 66 | Paul Strand# | 1.0 | 1913-1915 | |
| 76 | Fred Anderson# | 0.0 | 1909-1915 |
