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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Hooks Wiltse | 0.000 | 1906 | |
| 1 | Christy Mathewson# | 0.000 | 1906 | |
| 3 | Addie Joss | 0.529 | 1906 | |
| 4 | Cy Young | 0.667 | 1901 | |
| 5 | Addie Joss | 0.947 | 1905 | |
| 6 | Kid Nichols* | 1.000 | 1892 | |
| 6 | Joe Williams# | 1.000 | 1910 | |
| 6 | Eddie Plank# | 1.000 | 1908 | |
| 9 | Jeff Tesreau# | 1.059 | 1914 | |
| 9 | Russ Ford | 1.059 | 1910 | |
| 9 | Orval Overall | 1.059 | 1910 | |
| 12 | Jack Chesbro | 1.385 | 1907 | |
| 13 | Babe Adams# | 1.473 | 1913 | |
| 14 | Babe Adams# | 1.500 | 1914 | |
| 14 | Mordecai Brown# | 1.500 | 1909 | |
| 14 | Rube Waddell | 1.500 | 1903 | |
| 17 | Harry Krause | 1.688 | 1909 | |
| 18 | Joe Wood# | 1.895 | 1915 | |
| 19 | Frank Smith | 1.929 | 1908 | |
| 20 | Christy Mathewson# | 2.000 | 1904 | |
| 20 | Jesse Tannehill | 2.000 | 1903 | |
| 22 | Jesse Tannehill | 2.250 | 1901 | |
| 22 | Orval Overall | 2.250 | 1909 | |
| 24 | George McQuillan# | 2.328 | 1908 | |
| 25 | Rube Waddell | 2.348 | 1901 | |
| 26 | Christy Mathewson# | 2.500 | 1911 | |
| 27 | Dutch Leonard# | 2.647 | 1914 | |
| 27 | Doc White | 2.647 | 1906 | |
| 29 | Rube Waddell | 2.700 | 1902 | |
| 29 | Bill Donovan# | 2.700 | 1907 | |
| 31 | Weldon Henley | 2.755 | 1903 | |
| 32 | Charles Bender# | 2.812 | 1909 | |
| 32 | Rube Waddell | 2.812 | 1908 | |
| 34 | Charles Bender# | 2.893 | 1903 | |
| 35 | Charles Bender# | 2.953 | 1912 | |
| 36 | Cy Young | 3.000 | 1892 | |
| 36 | Tom Hughes | 3.000 | 1909 | |
| 36 | George Mullin | 3.000 | 1907 | |
| 36 | Charles Bender# | 3.000 | 1911 | |
| 40 | Bill Bernhard | 3.375 | 1906 | |
| 41 | Charles Bender# | 3.500 | 1908 | |
| 41 | Red Ames# | 3.500 | 1905 | |
| 43 | Claude Hendrix# | 3.600 | 1912 | |
| 44 | Charles Bender# | 3.635 | 1913 | |
| 45 | Joe Lake | 3.706 | 1910 | |
| 46 | Mordecai Brown# | 3.938 | 1910 | |
| 47 | Jack Pfiester | 4.000 | 1907 | |
| 47 | Vean Gregg# | 4.000 | 1911 | |
| 47 | Dutch Leonard# | 4.000 | 1915 | |
| 50 | Mordecai Brown# | 4.014 | 1907 | |
| 51 | Rube Marquard# | 4.235 | 1911 | |
| 51 | Charlie Smith | 4.235 | 1907 | |
| 53 | Otto Hess | 4.500 | 1906 | |
| 54 | Jeff Tesreau# | 4.860 | 1915 | |
| 55 | George Winter | 5.318 | 1901 | |
| 56 | Rube Marquard# | 5.400 | 1914 | |
| 57 | Eddie Plank# | 5.500 | 1903 | |
| 58 | George McConnell# | 5.510 | 1913 | |
| 59 | Vean Gregg# | 5.940 | 1913 | |
| 60 | Red Ames# | 7.043 | 1911 |
