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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Babe Ruth* | 380 | 1914-1935 | |
| 2 | Mel Ott* | 290 | 1927-1946 | |
| 3 | Ted Strong# | 286 | 1936-1954 | |
| 4 | Chuck Klein | 266 | 1928-1940 | |
| 5 | Rap Dixon | 159 | 1924-1947 | |
| 6 | Monte Irvin# | 136 | 1939-1954 | |
| 7 | Ron Northey# | 133 | 1942-1950 | |
| 8 | Sam Thompson | 127 | 1885-1898 | |
| 9 | Bill Nicholson | 120 | 1936-1953 | |
| 10 | Frank Schulte | 118 | 1904-1918 | |
| 11 | Roy Cullenbine# | 117 | 1938-1954 | |
| 12 | Bruce Campbell# | 111 | 1931-1954 | |
| 13 | Gavvy Cravath | 110 | 1908-1920 | |
| 14 | Heavy Johnson* | 103 | 1916-1932 | |
| 15 | Charlie Smith | 102 | 1925-1931 | |
| 16 | Harry Heilmann* | 98 | 1914-1931 | |
| 17 | Charlie Blackwell | 97 | 1915-1929 | |
| 18 | Enos Slaughter# | 96 | 1938-1954 | |
| 19 | Ival Goodman | 94 | 1935-1953 | |
| 20 | Willard Marshall# | 91 | 1942-1954 | |
| 21 | Wild Bill Wright# | 85 | 1933-1954 | |
| 22 | Stan Musial# | 84 | 1941-1954 | |
| 22 | Elmer Smith | 84 | 1914-1925 | |
| 24 | Andy Pafko# | 81 | 1943-1954 | |
| 24 | Dixie Walker# | 81 | 1931-1954 | |
| 26 | Bob Meusel | 79 | 1920-1930 | |
| 27 | Hank Bauer# | 78 | 1949-1954 | |
| 27 | Kiki Cuyler | 78 | 1922-1943 | |
| 29 | Paul Waner | 76 | 1926-1948 | |
| 30 | Owen Wilson | 75 | 1908-1916 | |
| 31 | Socks Seybold | 73 | 1899-1908 | |
| 32 | Bullet Rogan* | 71 | 1915-1934 | |
| 33 | Sam Crawford* | 70 | 1899-1917 | |
| 34 | George Selkirk | 69 | 1934-1944 | |
| 34 | Earl Webb | 69 | 1927-1933 | |
| 36 | Ripper Collins | 66 | 1931-1939 | |
| 36 | Carl Furillo# | 66 | 1946-1954 | |
| 38 | Frank Demaree | 65 | 1932-1943 | |
| 38 | Del Ennis# | 65 | 1946-1954 | |
| 40 | Vic Wertz# | 63 | 1947-1954 | |
| 41 | Tommy Henrich# | 61 | 1937-1954 | |
| 42 | Cy Williams | 60 | 1912-1930 | |
| 43 | Martin Dihigo | 57 | 1924-1946 | |
| 44 | Elmer Flick | 54 | 1898-1910 | |
| 44 | Harry Lumley | 54 | 1904-1910 | |
| 44 | Al Smith# | 54 | 1948-1954 | |
| 47 | Sam Mele# | 51 | 1947-1954 | |
| 48 | Harry Hooper | 50 | 1909-1925 | |
| 48 | Reb Russell | 50 | 1913-1923 | |
| 50 | Johnny Moore | 49 | 1928-1937 | |
| 51 | Hank Leiber | 48 | 1934-1945 | |
| 51 | Wally Westlake# | 48 | 1947-1954 | |
| 53 | Babe Herman | 47 | 1926-1937 | |
| 54 | Chet Laabs | 46 | 1937-1948 | |
| 55 | Dom DiMaggio# | 45 | 1940-1954 | |
| 56 | Jules Thomas | 44 | 1908-1926 | |
| 57 | Pete Fox | 42 | 1933-1944 | |
| 58 | Gus Bell# | 40 | 1950-1954 | |
| 58 | Frank Brower | 40 | 1920-1924 | |
| 58 | Phil Cavarretta | 40 | 1934-1951 | |
| 58 | Buck Freeman | 40 | 1891-1907 | |
| 62 | Wally Moses# | 39 | 1935-1954 | |
| 62 | Dave Robertson | 39 | 1913-1922 | |
| 64 | Gene Moore | 38 | 1931-1954 | |
| 65 | Buddy Lewis# | 37 | 1935-1954 | |
| 65 | Pat Mullin# | 37 | 1940-1954 | |
| 67 | Hank Edwards | 36 | 1942-1952 | |
| 68 | Hugh Duffy* | 35 | 1888-1905 | |
| 68 | Casey Stengel | 35 | 1912-1925 | |
| 70 | Tommy Griffith | 34 | 1913-1925 | |
| 70 | Danny Murphy | 34 | 1900-1912 | |
| 70 | John Stone | 34 | 1928-1950 | |
| 73 | Beau Bell | 33 | 1935-1944 | |
| 73 | Ty Cobb* | 33 | 1905-1928 | |
| 73 | Tommy Holmes | 33 | 1942-1951 | |
| 73 | Hurley McNair | 33 | 1910-1928 | |
| 73 | Pat Seerey# | 33 | 1943-1948 | |
| 78 | George Kelly | 32 | 1915-1932 | |
| 78 | Stan Spence# | 32 | 1940-1954 | |
| 80 | Pepper Martin | 30 | 1929-1941 | |
| 80 | Johnny Wyrostek# | 30 | 1945-1954 | |
| 82 | Jack Tobin | 29 | 1914-1927 | |
| 82 | Ross Youngs | 29 | 1917-1926 | |
| 84 | Joe Grace# | 28 | 1938-1954 | |
| 84 | Smead Jolley | 28 | 1930-1933 | |
| 84 | Harry Rice | 28 | 1924-1933 | |
| 84 | Billy Southworth | 28 | 1914-1929 | |
| 84 | Al Zarilla | 28 | 1943-1953 | |
| 89 | Ike Boone | 27 | 1922-1932 | |
| 89 | George Watkins | 27 | 1930-1936 | |
| 91 | Charlie Hickman | 26 | 1897-1908 | |
| 91 | Willie Keeler* | 26 | 1892-1910 | |
| 91 | Hank Sauer# | 26 | 1942-1954 | |
| 94 | Charlie Keller | 25 | 1939-1950 | |
| 95 | Bob Seeds | 24 | 1930-1952 | |
| 96 | Roy Johnson | 23 | 1929-1940 | |
| 96 | Ben Paschal | 23 | 1917-1929 | |
| 98 | Augie Bergamo# | 22 | 1944-1954 | |
| 98 | Sid Gordon# | 22 | 1941-1954 | |
| 98 | Jackie Jensen# | 22 | 1951-1954 |
