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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Joe DiMaggio# | 332 | 1936-1954 | |
| 2 | Larry Doby# | 219 | 1943-1954 | |
| 3 | Oscar Charleston* | 210 | 1916-1942 | |
| 4 | Martin Dihigo | 201 | 1924-1946 | |
| 5 | Earl Averill | 196 | 1929-1940 | |
| 6 | Sam Jethroe# | 184 | 1938-1954 | |
| 7 | Willard Brown# | 178 | 1935-1954 | |
| 8 | Duke Snider# | 174 | 1948-1954 | |
| 9 | Turkey Stearnes | 172 | 1923-1946 | |
| 10 | Vince DiMaggio# | 168 | 1937-1954 | |
| 11 | Hack Wilson | 155 | 1923-1934 | |
| 12 | Babe Ruth* | 136 | 1914-1935 | |
| 13 | Monte Irvin# | 132 | 1939-1954 | |
| 14 | Willie Mays# | 124 | 1951-1954 | |
| 15 | Terry Moore# | 112 | 1935-1954 | |
| 16 | Tris Speaker* | 111 | 1907-1928 | |
| 17 | Wally Berger | 106 | 1930-1944 | |
| 18 | Henry Kimbro# | 102 | 1937-1954 | |
| 19 | Andy Pafko# | 99 | 1943-1954 | |
| 20 | Ty Cobb* | 94 | 1905-1928 | |
| 21 | Cy Williams | 92 | 1912-1930 | |
| 22 | Mel Ott* | 90 | 1927-1946 | |
| 23 | Mickey Mantle# | 88 | 1951-1954 | |
| 23 | Jimmy Ryan | 88 | 1885-1903 | |
| 25 | Cristobal Torriente | 86 | 1912-1928 | |
| 26 | Jules Thomas | 72 | 1908-1926 | |
| 27 | Sam West | 70 | 1927-1940 | |
| 28 | Alejandro Oms | 69 | 1917-1935 | |
| 29 | Bullet Rogan* | 67 | 1915-1934 | |
| 30 | Hank Leiber | 66 | 1934-1945 | |
| 30 | Bobby Thomson# | 66 | 1946-1954 | |
| 32 | Wally Judnich | 64 | 1940-1948 | |
| 33 | Cy Seymour* | 61 | 1896-1913 | |
| 34 | Al Simmons* | 58 | 1924-1941 | |
| 35 | Pete Hill | 55 | 1904-1923 | |
| 36 | Stan Musial# | 53 | 1941-1954 | |
| 37 | Gene Moore | 52 | 1931-1954 | |
| 38 | Cool Papa Bell | 51 | 1924-1945 | |
| 39 | Frank Thomas# | 50 | 1952-1954 | |
| 40 | Johnny Frederick | 48 | 1929-1934 | |
| 41 | Ginger Beaumont | 43 | 1899-1910 | |
| 41 | Milt Byrnes# | 43 | 1943-1954 | |
| 41 | Carl Reynolds | 43 | 1927-1948 | |
| 44 | Johnny Groth# | 42 | 1948-1954 | |
| 44 | Fred Schulte | 42 | 1927-1939 | |
| 46 | Earle Combs | 41 | 1924-1935 | |
| 46 | Ira Flagstead | 41 | 1918-1930 | |
| 48 | Dummy Hoy | 40 | 1888-1902 | |
| 48 | Joe Marty | 40 | 1937-1948 | |
| 48 | Edd Roush | 40 | 1916-1931 | |
| 48 | Wild Bill Wright# | 40 | 1933-1954 | |
| 52 | George Van Haltren | 39 | 1887-1903 | |
| 53 | Hugh Duffy* | 38 | 1888-1905 | |
| 53 | John Stone | 38 | 1928-1950 | |
| 55 | Ival Goodman | 37 | 1935-1953 | |
| 55 | Mule Haas | 37 | 1925-1943 | |
| 55 | Ray Powell | 37 | 1913-1924 | |
| 58 | Benny Kauff | 36 | 1915-1920 | |
| 59 | Clyde Vollmer# | 34 | 1946-1954 | |
| 60 | Dom DiMaggio# | 33 | 1940-1954 | |
| 61 | Frenchy Bordagaray# | 32 | 1934-1954 | |
| 61 | Chet Laabs | 32 | 1937-1948 | |
| 61 | Clint Thomas | 32 | 1920-1941 | |
| 64 | Ethan Allen | 31 | 1926-1944 | |
| 64 | Danny Taylor | 31 | 1926-1936 | |
| 66 | Buster Adams# | 30 | 1939-1954 | |
| 66 | Chick Hafey | 30 | 1924-1945 | |
| 66 | Mike Kreevich | 30 | 1931-1945 | |
| 69 | Billy Hamilton* | 29 | 1888-1901 | |
| 69 | Cliff Heathcote | 29 | 1918-1932 | |
| 69 | Ralph Kiner# | 29 | 1946-1954 | |
| 72 | Steve Brodie | 27 | 1890-1902 | |
| 73 | Ping Bodie | 26 | 1911-1921 | |
| 73 | Jimmy Ripple | 26 | 1936-1942 | |
| 73 | Max West | 26 | 1938-1947 | |
| 76 | Spottswood Poles | 25 | 1909-1923 | |
| 76 | Pete Reiser | 25 | 1940-1951 | |
| 78 | Freddie Lindstrom | 24 | 1924-1936 | |
| 78 | Jo-Jo Moore | 24 | 1932-1954 | |
| 78 | Bill Wilson# | 24 | 1953-1954 | |
| 81 | Jim Busby# | 23 | 1950-1954 | |
| 81 | Sam Crawford* | 23 | 1899-1917 | |
| 81 | Billy Southworth | 23 | 1914-1929 | |
| 84 | Mike Donlin | 22 | 1899-1913 | |
| 84 | Hoot Evers# | 22 | 1946-1953 | |
| 84 | Harry Rice | 22 | 1924-1933 | |
| 87 | Phil Cavarretta | 21 | 1934-1951 | |
| 88 | Sammy Byrd | 20 | 1929-1936 | |
| 88 | Carl Furillo# | 20 | 1946-1954 | |
| 88 | Johnny Hopp | 20 | 1939-1952 | |
| 88 | Les Mann | 20 | 1913-1928 | |
| 88 | Bernie Neis | 20 | 1920-1927 | |
| 88 | Denny Sothern | 20 | 1926-1931 | |
| 88 | Wally Westlake# | 20 | 1947-1954 | |
| 95 | Mandy Brooks | 19 | 1925-1926 | |
| 95 | Baby Doll Jacobson | 19 | 1915-1927 | |
| 95 | Dode Paskert | 19 | 1907-1921 | |
| 98 | Harry Craft | 18 | 1937-1948 | |
| 98 | Tommy Holmes | 18 | 1942-1951 | |
| 98 | Heinie Manush | 18 | 1923-1938 |
