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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ted Williams# | 417 | 1939-1954 | |
| 2 | Al Simmons* | 230 | 1924-1941 | |
| 3 | Goose Goslin | 220 | 1921-1941 | |
| 4 | Charlie Keller | 188 | 1939-1950 | |
| 5 | Bob Johnson | 172 | 1933-1951 | |
| 6 | Joe Medwick | 169 | 1932-1947 | |
| 7 | Jeff Heath# | 162 | 1936-1954 | |
| 8 | Chick Hafey | 155 | 1924-1945 | |
| 8 | Tommy Henrich# | 155 | 1937-1954 | |
| 10 | Ralph Kiner# | 152 | 1946-1954 | |
| 11 | Zack Wheat* | 134 | 1909-1927 | |
| 11 | Ken Williams | 134 | 1915-1929 | |
| 13 | Del Ennis# | 120 | 1946-1954 | |
| 14 | Lefty O'Doul | 106 | 1922-1934 | |
| 15 | Bill Nicholson | 101 | 1936-1953 | |
| 16 | Wally Berger | 100 | 1930-1944 | |
| 17 | Stan Musial# | 97 | 1941-1954 | |
| 18 | Gus Zernial# | 92 | 1949-1954 | |
| 19 | Sherry Magee | 88 | 1904-1919 | |
| 19 | Butch Nieman# | 88 | 1943-1954 | |
| 21 | Ed Delahanty* | 87 | 1888-1903 | |
| 22 | Hank Greenberg# | 84 | 1932-1954 | |
| 23 | Mule Suttles | 79 | 1923-1945 | |
| 24 | Stan Spence# | 78 | 1940-1954 | |
| 25 | Willard Brown# | 77 | 1935-1954 | |
| 26 | Dale Mitchell# | 75 | 1946-1954 | |
| 26 | Hank Sauer# | 75 | 1942-1954 | |
| 28 | Roy Parnell | 73 | 1927-1949 | |
| 29 | Fred Clarke* | 72 | 1894-1912 | |
| 30 | Danny Litwhiler | 71 | 1940-1950 | |
| 31 | Sam Chapman# | 69 | 1938-1954 | |
| 32 | George Harper | 68 | 1916-1929 | |
| 32 | Minnie Minoso# | 68 | 1946-1954 | |
| 34 | Jesse Burkett* | 67 | 1890-1905 | |
| 34 | Joe Vosmik | 67 | 1931-1941 | |
| 36 | Joe Jackson* | 65 | 1908-1923 | |
| 37 | Babe Ruth* | 62 | 1914-1935 | |
| 38 | Jimmy Sheckard | 60 | 1897-1913 | |
| 39 | Tilly Walker | 59 | 1911-1923 | |
| 40 | Mel Ott* | 57 | 1927-1946 | |
| 40 | John Stone | 57 | 1928-1950 | |
| 40 | Clint Thomas | 57 | 1920-1941 | |
| 43 | George Selkirk | 56 | 1934-1944 | |
| 43 | Gee Walker | 56 | 1931-1942 | |
| 45 | Hurley McNair | 54 | 1910-1928 | |
| 46 | Goody Rosen# | 51 | 1937-1954 | |
| 46 | Moose Solters | 51 | 1934-1942 | |
| 46 | Vic Wertz# | 51 | 1947-1954 | |
| 49 | Gene Hermanski# | 49 | 1943-1954 | |
| 49 | Irish Meusel | 49 | 1914-1927 | |
| 49 | Wilson Redus | 49 | 1924-1935 | |
| 52 | Kiki Cuyler | 48 | 1922-1943 | |
| 53 | Roy Cullenbine# | 47 | 1938-1954 | |
| 53 | Joe Kelley | 47 | 1891-1908 | |
| 55 | Vic Harris | 45 | 1925-1939 | |
| 55 | Heinie Manush | 45 | 1923-1938 | |
| 57 | Joe DiMaggio# | 43 | 1936-1954 | |
| 57 | Bobby Veach | 43 | 1912-1925 | |
| 59 | Bibb Falk | 41 | 1920-1931 | |
| 59 | Danny Gardella# | 41 | 1944-1948 | |
| 59 | Jo-Jo Moore | 41 | 1932-1954 | |
| 59 | Cy Williams | 41 | 1912-1930 | |
| 63 | Ray Blades | 40 | 1922-1931 | |
| 63 | Ben Chapman | 40 | 1930-1944 | |
| 63 | Johnny Rizzo | 40 | 1938-1941 | |
| 66 | Beals Becker | 39 | 1908-1915 | |
| 66 | Kip Selbach | 39 | 1894-1906 | |
| 68 | Max Carey | 38 | 1910-1929 | |
| 69 | Hugh Duffy* | 37 | 1888-1905 | |
| 69 | Johnny Lindell | 37 | 1941-1950 | |
| 69 | Cristobal Torriente | 37 | 1912-1928 | |
| 72 | Bill Howerton# | 36 | 1949-1954 | |
| 73 | Happy Felsch | 35 | 1915-1920 | |
| 73 | Fats Jenkins | 35 | 1920-1936 | |
| 73 | Curt Walker | 35 | 1919-1930 | |
| 76 | Mike Donlin | 34 | 1899-1913 | |
| 76 | Monte Irvin# | 34 | 1939-1954 | |
| 78 | Freddy Leach | 33 | 1923-1932 | |
| 78 | Whitey Lockman# | 33 | 1945-1954 | |
| 78 | Hersh Martin | 33 | 1937-1954 | |
| 78 | Riggs Stephenson | 33 | 1921-1934 | |
| 82 | Elmer Smith | 32 | 1886-1901 | |
| 83 | Milt Byrnes# | 31 | 1943-1954 | |
| 83 | Hoot Evers# | 31 | 1946-1953 | |
| 83 | Smead Jolley | 31 | 1930-1933 | |
| 86 | Joe Adcock# | 30 | 1950-1954 | |
| 86 | Jules Thomas | 30 | 1908-1926 | |
| 88 | Charles Earle | 29 | 1906-1919 | |
| 88 | Topsy Hartsel | 29 | 1898-1911 | |
| 88 | Len Koenecke | 29 | 1932-1935 | |
| 91 | Dusty Rhodes# | 28 | 1952-1954 | |
| 91 | Eric Tipton# | 28 | 1939-1954 | |
| 93 | Tommy Holmes | 27 | 1942-1951 | |
| 93 | Turkey Stearnes | 27 | 1923-1946 | |
| 93 | Coaker Triplett# | 27 | 1938-1954 | |
| 96 | Walton Cruise | 26 | 1914-1923 | |
| 96 | Rip Repulski# | 26 | 1953-1954 | |
| 96 | Carl Reynolds | 26 | 1927-1948 | |
| 96 | Enos Slaughter# | 26 | 1938-1954 | |
| 96 | George Stone | 26 | 1903-1910 |
