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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heathcliff Slocumb RP | 0 | 0 | 0 | 0.00 | 1 | 0 | 2.0 | 3 | 0 | 0 | 0 | 0 | 2 | 1.50 | .333 | .429 | 0.1 |
| Hideki Okajima RP | 0 | 0 | 0 | 0.00 | 3 | 0 | 4.1 | 2 | 0 | 0 | 0 | 0 | 3 | 0.46 | .133 | .167 | 0.1 |
| Derek Lowe RP | 0 | 0 | 0 | 0.00 | 1 | 0 | 1.2 | 0 | 0 | 0 | 0 | 0 | 1 | 0.00 | .000 | .000 | 0.0 |
| Tom Gordon RP | 8 | 1 | 3 | 1.14 | 47 | 0 | 55.1 | 46 | 7 | 7 | 2 | 15 | 47 | 1.10 | .232 | .291 | 1.1 |
| Ellis Kinder RP | 0 | 0 | 0 | 2.08 | 2 | 0 | 4.1 | 7 | 2 | 1 | 0 | 2 | 4 | 2.08 | .368 | .467 | 0.1 |
| Daniel Bard RP | 7 | 0 | 0 | 2.45 | 26 | 0 | 33.0 | 30 | 9 | 9 | 1 | 10 | 28 | 1.21 | .244 | .302 | 0.4 |
| Luis Tiant RP | 2 | 1 | 1 | 2.70 | 22 | 0 | 56.2 | 45 | 18 | 17 | 5 | 18 | 52 | 1.11 | .216 | .263 | 0.3 |
| Jonathan Papelbon CL | 2 | 7 | 28 | 3.26 | 49 | 0 | 47.0 | 43 | 17 | 17 | 4 | 14 | 65 | 1.21 | .238 | .348 | 1.3 |
| Bill Gatewood SP | 7 | 10 | 0 | 3.95 | 26 | 26 | 148.0 | 143 | 70 | 65 | 10 | 35 | 140 | 1.20 | .255 | .317 | 3.1 |
| Dutch H Leonard SP | 7 | 10 | 0 | 4.04 | 24 | 24 | 147.0 | 138 | 67 | 66 | 19 | 47 | 110 | 1.26 | .248 | .277 | 0.2 |
| Jon Lester RP | 3 | 1 | 1 | 4.06 | 29 | 0 | 57.2 | 54 | 26 | 26 | 6 | 15 | 55 | 1.20 | .242 | .293 | 0.2 |
| Tim Wakefield RP | 2 | 0 | 0 | 4.11 | 13 | 0 | 35.0 | 28 | 16 | 16 | 3 | 16 | 34 | 1.26 | .224 | .284 | 0.0 |
| Cy Young SP | 12 | 12 | 0 | 4.14 | 30 | 30 | 191.1 | 212 | 94 | 88 | 23 | 30 | 141 | 1.26 | .275 | .309 | 2.0 |
| Tom Burgmeier RP | 1 | 0 | 0 | 4.37 | 26 | 0 | 35.0 | 43 | 18 | 17 | 2 | 6 | 27 | 1.40 | .307 | .360 | 0.2 |
| Smoky Joe Wood SP | 7 | 10 | 0 | 4.43 | 29 | 29 | 156.1 | 168 | 83 | 77 | 11 | 57 | 127 | 1.44 | .275 | .326 | 1.5 |
| Dick Radatz RP | 2 | 4 | 7 | 4.44 | 56 | 0 | 52.2 | 50 | 26 | 26 | 6 | 23 | 50 | 1.39 | .253 | .308 | -0.1 |
| Roger Clemens SP | 7 | 10 | 0 | 4.78 | 26 | 26 | 141.1 | 141 | 80 | 75 | 12 | 50 | 128 | 1.35 | .256 | .311 | 1.7 |
| Dick Drago RP | 0 | 0 | 0 | 5.79 | 2 | 0 | 4.2 | 3 | 3 | 3 | 1 | 1 | 2 | 0.86 | .188 | .154 | -0.2 |
| Mel Parnell RP | 0 | 2 | 0 | 6.39 | 13 | 0 | 25.1 | 44 | 25 | 18 | 5 | 10 | 16 | 2.13 | .379 | .406 | -0.7 |
