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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dan Spillner RP | 0 | 0 | 0 | 0.00 | 2 | 0 | 3.0 | 0 | 0 | 0 | 0 | 0 | 4 | 0.00 | .000 | .000 | 0.2 |
| Addie Joss RP | 8 | 3 | 6 | 1.78 | 53 | 0 | 55.2 | 46 | 13 | 11 | 1 | 10 | 31 | 1.01 | .219 | .253 | 1.6 |
| Corey Kluber SP | 16 | 13 | 0 | 2.75 | 34 | 34 | 248.2 | 201 | 83 | 76 | 22 | 59 | 167 | 1.05 | .220 | .246 | 3.9 |
| Sam McDowell RP | 1 | 0 | 0 | 2.88 | 22 | 0 | 56.1 | 36 | 20 | 18 | 6 | 23 | 53 | 1.05 | .180 | .210 | 0.1 |
| Sonny Siebert RP | 0 | 0 | 0 | 2.89 | 9 | 0 | 18.2 | 20 | 6 | 6 | 2 | 1 | 17 | 1.12 | .270 | .327 | 0.3 |
| Chris Perez RP | 0 | 0 | 0 | 3.00 | 3 | 0 | 3.0 | 2 | 1 | 1 | 0 | 0 | 4 | 0.67 | .182 | .286 | 0.1 |
| Cliff P Lee SP | 16 | 9 | 0 | 3.06 | 33 | 33 | 235.1 | 200 | 83 | 80 | 29 | 37 | 187 | 1.01 | .229 | .258 | 3.8 |
| CC Sabathia SP | 11 | 12 | 0 | 3.32 | 33 | 33 | 225.1 | 209 | 93 | 83 | 25 | 42 | 199 | 1.11 | .246 | .292 | 4.3 |
| Rafael Betancourt CL | 6 | 8 | 32 | 3.62 | 63 | 0 | 59.2 | 60 | 24 | 24 | 4 | 17 | 44 | 1.29 | .256 | .299 | 1.0 |
| Bob Wickman RP | 1 | 0 | 0 | 3.81 | 19 | 0 | 28.1 | 24 | 12 | 12 | 3 | 10 | 24 | 1.20 | .231 | .273 | 0.1 |
| Bob Feller SP | 14 | 11 | 0 | 3.86 | 33 | 33 | 200.2 | 168 | 90 | 86 | 13 | 102 | 162 | 1.35 | .225 | .267 | 2.3 |
| Doug Jones RP | 2 | 5 | 0 | 3.88 | 33 | 0 | 46.1 | 44 | 21 | 20 | 2 | 12 | 28 | 1.21 | .244 | .276 | 0.7 |
| Don Mossi RP | 1 | 0 | 1 | 4.00 | 12 | 0 | 18.0 | 12 | 8 | 8 | 2 | 6 | 17 | 1.00 | .190 | .227 | 0.1 |
| Jose Mesa RP | 1 | 1 | 0 | 4.12 | 20 | 0 | 24.0 | 25 | 15 | 11 | 2 | 8 | 18 | 1.38 | .263 | .299 | 0.1 |
| Stan Coveleski SP | 8 | 14 | 0 | 4.48 | 30 | 30 | 196.2 | 223 | 111 | 98 | 15 | 42 | 87 | 1.35 | .286 | .302 | 2.6 |
| Dave LaRoche RP | 1 | 1 | 1 | 5.13 | 25 | 0 | 33.1 | 36 | 22 | 19 | 6 | 15 | 31 | 1.53 | .269 | .306 | -0.4 |
| Mel Harder RP | 0 | 0 | 0 | 5.79 | 3 | 0 | 4.2 | 8 | 3 | 3 | 1 | 1 | 3 | 1.93 | .400 | .412 | -0.1 |
| Ray Narleski RP | 0 | 0 | 0 | 6.75 | 3 | 0 | 4.0 | 4 | 3 | 3 | 1 | 3 | 2 | 1.75 | .267 | .250 | -0.2 |
