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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heathcliff Slocumb RP | 1 | 0 | 0 | 0.00 | 2 | 0 | 2.1 | 0 | 0 | 0 | 0 | 1 | 1 | 0.43 | .000 | .000 | 0.0 |
| Hideki Okajima RP | 0 | 0 | 0 | 0.00 | 4 | 0 | 6.1 | 6 | 1 | 0 | 0 | 1 | 7 | 1.11 | .240 | .333 | 0.2 |
| Derek Lowe RP | 0 | 0 | 0 | 0.00 | 3 | 0 | 3.2 | 4 | 3 | 0 | 0 | 1 | 4 | 1.36 | .267 | .364 | 0.2 |
| Jonathan Papelbon CL | 3 | 2 | 38 | 1.66 | 58 | 0 | 59.2 | 31 | 12 | 11 | 3 | 12 | 55 | 0.72 | .151 | .188 | 1.7 |
| Dick Radatz RP | 9 | 2 | 6 | 2.05 | 59 | 0 | 48.1 | 41 | 11 | 11 | 3 | 18 | 44 | 1.22 | .233 | .295 | 0.7 |
| Dick Drago RP | 0 | 0 | 0 | 2.70 | 4 | 0 | 6.2 | 4 | 2 | 2 | 1 | 1 | 4 | 0.75 | .174 | .167 | -0.0 |
| Tom Burgmeier RP | 0 | 1 | 1 | 2.97 | 24 | 0 | 30.1 | 31 | 10 | 10 | 1 | 7 | 24 | 1.25 | .265 | .326 | 0.5 |
| Mel Parnell RP | 0 | 0 | 0 | 3.06 | 19 | 0 | 53.0 | 42 | 20 | 18 | 2 | 17 | 34 | 1.11 | .214 | .248 | 0.5 |
| Dutch H Leonard SP | 12 | 12 | 0 | 3.58 | 32 | 32 | 208.2 | 196 | 98 | 83 | 11 | 88 | 141 | 1.36 | .245 | .282 | 2.8 |
| Jon Lester SP | 14 | 6 | 0 | 3.65 | 31 | 31 | 189.2 | 177 | 77 | 77 | 25 | 57 | 176 | 1.23 | .247 | .294 | 2.1 |
| Tom Gordon RP | 6 | 3 | 2 | 3.79 | 46 | 0 | 57.0 | 61 | 28 | 24 | 5 | 18 | 57 | 1.39 | .270 | .339 | 1.0 |
| Cy Young SP | 13 | 18 | 0 | 3.93 | 34 | 34 | 235.2 | 246 | 110 | 103 | 18 | 44 | 165 | 1.23 | .267 | .304 | 4.7 |
| Luis Tiant RP | 1 | 3 | 1 | 3.94 | 26 | 0 | 48.0 | 45 | 21 | 21 | 7 | 19 | 41 | 1.33 | .247 | .284 | -0.2 |
| Smoky Joe Wood SP | 11 | 12 | 0 | 3.96 | 32 | 32 | 193.0 | 206 | 97 | 85 | 9 | 62 | 148 | 1.39 | .274 | .328 | 3.9 |
| Roger Clemens SP | 11 | 16 | 0 | 4.45 | 33 | 33 | 198.0 | 204 | 104 | 98 | 23 | 61 | 182 | 1.34 | .261 | .313 | 2.5 |
| Daniel Bard RP | 2 | 1 | 0 | 4.97 | 25 | 0 | 29.0 | 32 | 17 | 16 | 3 | 16 | 29 | 1.66 | .283 | .354 | -0.2 |
| Tim Wakefield RP | 1 | 2 | 0 | 5.00 | 22 | 0 | 68.1 | 69 | 42 | 38 | 8 | 24 | 61 | 1.36 | .253 | .293 | 0.0 |
| Scott Atchison RP | 0 | 0 | 0 | 5.40 | 3 | 0 | 3.1 | 4 | 2 | 2 | 1 | 1 | 1 | 1.50 | .286 | .250 | -0.1 |
| Ellis Kinder RP | 0 | 0 | 0 | 9.00 | 3 | 0 | 4.0 | 6 | 4 | 4 | 0 | 3 | 1 | 2.25 | .400 | .375 | -0.0 |
